ROR2 has a protective role in melanoma by inhibiting Akt activity, cell-cycle progression, and proliferation

BACKGROUND: Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a Wnt5a receptor aberrantly expressed in cancer that was shown to either suppress or promote carcinogenesis in different tumor types. Our goal was to study the role of ROR2 in melanoma. METHODS: Gain and loss-of-function strategie...

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Detalles Bibliográficos
Autores principales: Castro, María Victoria, Barbero, Gastón Alexis, Villanueva, María Belén, Grumolato, Luca, Nsengimana, Jérémie, Newton-Bishop, Julia, Illescas, Edith, Quezada, María Josefina, Lopez-Bergami, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590781/
https://www.ncbi.nlm.nih.gov/pubmed/34774050
http://dx.doi.org/10.1186/s12929-021-00776-w

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