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Epilepsy and the risk of severe coronavirus disease 2019 outcomes: A systematic review, meta-analysis, and meta-regression

BACKGROUND: Patients with epilepsy experience seizures, which have been reported to increase and worsen during the coronavirus disease (COVID-19) pandemic. However, the association between epilepsy and COVID-19 outcomes remains unclear. The aim of this study was to analyze whether patients with epil...

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Autores principales: Siahaan, Yusak Mangara Tua, Ketaren, Retno Jayantri, Hartoyo, Vinson, Hariyanto, Timotius Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590948/
https://www.ncbi.nlm.nih.gov/pubmed/34839246
http://dx.doi.org/10.1016/j.yebeh.2021.108437
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author Siahaan, Yusak Mangara Tua
Ketaren, Retno Jayantri
Hartoyo, Vinson
Hariyanto, Timotius Ivan
author_facet Siahaan, Yusak Mangara Tua
Ketaren, Retno Jayantri
Hartoyo, Vinson
Hariyanto, Timotius Ivan
author_sort Siahaan, Yusak Mangara Tua
collection PubMed
description BACKGROUND: Patients with epilepsy experience seizures, which have been reported to increase and worsen during the coronavirus disease (COVID-19) pandemic. However, the association between epilepsy and COVID-19 outcomes remains unclear. The aim of this study was to analyze whether patients with epilepsy have an increased risk of having poor COVID-19 outcomes. METHODS: We comprehensively evaluated potential articles extracted from the medRxiv, Europe PMC, and PubMed databases until June 30, 2021, using selected keywords. All published studies on epilepsy and COVID-19 were selected. We used the Review Manager 5.4 and Comprehensive Meta-Analysis 3 software for statistical analysis. RESULTS: Thirteen studies with 67,131 patients with COVID-19 were included in the analysis. Evaluation of the collated data revealed an association between epilepsy and increased severity of COVID-19 (OR, 1.69; 95%CI: 1.11–2.59; p = 0.010; I(2) = 29%; random-effect modeling) and mortality from COVID-19 (OR, 1.71; 95%CI: 1.14–2.56; p = 0.010; I(2) = 53%; random-effect modeling). The results also showed that the association between epilepsy and increased risk of developing severe COVID-19 is influenced by sex and neurodegenerative disease. CONCLUSIONS: The findings of this study suggest that patients with epilepsy are at risk of having poor COVID-19 outcomes. Patients with epilepsy need special attention and should be prioritized for administration of the COVID-19 vaccine. Registration details: PROSPERO (CRD42021264979).
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spelling pubmed-85909482021-11-15 Epilepsy and the risk of severe coronavirus disease 2019 outcomes: A systematic review, meta-analysis, and meta-regression Siahaan, Yusak Mangara Tua Ketaren, Retno Jayantri Hartoyo, Vinson Hariyanto, Timotius Ivan Epilepsy Behav Review BACKGROUND: Patients with epilepsy experience seizures, which have been reported to increase and worsen during the coronavirus disease (COVID-19) pandemic. However, the association between epilepsy and COVID-19 outcomes remains unclear. The aim of this study was to analyze whether patients with epilepsy have an increased risk of having poor COVID-19 outcomes. METHODS: We comprehensively evaluated potential articles extracted from the medRxiv, Europe PMC, and PubMed databases until June 30, 2021, using selected keywords. All published studies on epilepsy and COVID-19 were selected. We used the Review Manager 5.4 and Comprehensive Meta-Analysis 3 software for statistical analysis. RESULTS: Thirteen studies with 67,131 patients with COVID-19 were included in the analysis. Evaluation of the collated data revealed an association between epilepsy and increased severity of COVID-19 (OR, 1.69; 95%CI: 1.11–2.59; p = 0.010; I(2) = 29%; random-effect modeling) and mortality from COVID-19 (OR, 1.71; 95%CI: 1.14–2.56; p = 0.010; I(2) = 53%; random-effect modeling). The results also showed that the association between epilepsy and increased risk of developing severe COVID-19 is influenced by sex and neurodegenerative disease. CONCLUSIONS: The findings of this study suggest that patients with epilepsy are at risk of having poor COVID-19 outcomes. Patients with epilepsy need special attention and should be prioritized for administration of the COVID-19 vaccine. Registration details: PROSPERO (CRD42021264979). Elsevier Inc. 2021-12 2021-11-15 /pmc/articles/PMC8590948/ /pubmed/34839246 http://dx.doi.org/10.1016/j.yebeh.2021.108437 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Siahaan, Yusak Mangara Tua
Ketaren, Retno Jayantri
Hartoyo, Vinson
Hariyanto, Timotius Ivan
Epilepsy and the risk of severe coronavirus disease 2019 outcomes: A systematic review, meta-analysis, and meta-regression
title Epilepsy and the risk of severe coronavirus disease 2019 outcomes: A systematic review, meta-analysis, and meta-regression
title_full Epilepsy and the risk of severe coronavirus disease 2019 outcomes: A systematic review, meta-analysis, and meta-regression
title_fullStr Epilepsy and the risk of severe coronavirus disease 2019 outcomes: A systematic review, meta-analysis, and meta-regression
title_full_unstemmed Epilepsy and the risk of severe coronavirus disease 2019 outcomes: A systematic review, meta-analysis, and meta-regression
title_short Epilepsy and the risk of severe coronavirus disease 2019 outcomes: A systematic review, meta-analysis, and meta-regression
title_sort epilepsy and the risk of severe coronavirus disease 2019 outcomes: a systematic review, meta-analysis, and meta-regression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590948/
https://www.ncbi.nlm.nih.gov/pubmed/34839246
http://dx.doi.org/10.1016/j.yebeh.2021.108437
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