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Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population
BACKGROUND: Some studies have reported that chronic kidney disease (CKD) or the estimated glomerular filtration rate (eGFR) is significantly associated with metabolic abnormalities. METHODS: Six hundred forty-six community residents aged 45–60 years without overt renal dysfunction were recruited in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590978/ https://www.ncbi.nlm.nih.gov/pubmed/34785920 http://dx.doi.org/10.2147/DMSO.S337190 |
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author | Wang, Xichang Wang, Haoyu Li, Jiashu Gao, Xiaotong Han, Yutong Teng, Weiping Shan, Zhongyan Lai, Yaxin |
author_facet | Wang, Xichang Wang, Haoyu Li, Jiashu Gao, Xiaotong Han, Yutong Teng, Weiping Shan, Zhongyan Lai, Yaxin |
author_sort | Wang, Xichang |
collection | PubMed |
description | BACKGROUND: Some studies have reported that chronic kidney disease (CKD) or the estimated glomerular filtration rate (eGFR) is significantly associated with metabolic abnormalities. METHODS: Six hundred forty-six community residents aged 45–60 years without overt renal dysfunction were recruited in this cross-sectional study. eGFR was estimated by serum creatinine measurement. The visceral fat area (VFA) and subcutaneous fat area (SFA) were assessed by magnetic resonance imaging (MRI). The body mass index (BMI) and waist-hip ratio (WHR) were also evaluated. Additionally, we tested the subjects’ blood lipid levels to diagnose dyslipidemia. RESULTS: Compared with the subjects with neither dyslipidemia nor obesity, men with both dyslipidemia and high obesity indices, such as BMI, WHR and VFA, showed a significantly lower mean eGFR; women with dyslipidemia with high WHR, VFA or SFA also showed a significantly lower mean eGFR. Although an independent association between the metabolic variables and eGFR was not found except for BMI, some of the combined effects of each variable were related to eGFR decline. Comorbidity of dyslipidemia and high WHR was significant risk factor for eGFR reduction (β −8.805, SD 4.116, p < 0.05). Additionally, comorbidity of dyslipidemia and high obesity indices such as BMI (β −12.942, SD 5.268, p < 0.05) and VFA (β −7.069, SD 3.394, p < 0.05) were significant risk factors for eGFR reduction in men. CONCLUSION: The combined effect of dyslipidemia and high obesity indices is significantly related to the decline in eGFR. The association is more profound in men. |
format | Online Article Text |
id | pubmed-8590978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-85909782021-11-15 Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population Wang, Xichang Wang, Haoyu Li, Jiashu Gao, Xiaotong Han, Yutong Teng, Weiping Shan, Zhongyan Lai, Yaxin Diabetes Metab Syndr Obes Original Research BACKGROUND: Some studies have reported that chronic kidney disease (CKD) or the estimated glomerular filtration rate (eGFR) is significantly associated with metabolic abnormalities. METHODS: Six hundred forty-six community residents aged 45–60 years without overt renal dysfunction were recruited in this cross-sectional study. eGFR was estimated by serum creatinine measurement. The visceral fat area (VFA) and subcutaneous fat area (SFA) were assessed by magnetic resonance imaging (MRI). The body mass index (BMI) and waist-hip ratio (WHR) were also evaluated. Additionally, we tested the subjects’ blood lipid levels to diagnose dyslipidemia. RESULTS: Compared with the subjects with neither dyslipidemia nor obesity, men with both dyslipidemia and high obesity indices, such as BMI, WHR and VFA, showed a significantly lower mean eGFR; women with dyslipidemia with high WHR, VFA or SFA also showed a significantly lower mean eGFR. Although an independent association between the metabolic variables and eGFR was not found except for BMI, some of the combined effects of each variable were related to eGFR decline. Comorbidity of dyslipidemia and high WHR was significant risk factor for eGFR reduction (β −8.805, SD 4.116, p < 0.05). Additionally, comorbidity of dyslipidemia and high obesity indices such as BMI (β −12.942, SD 5.268, p < 0.05) and VFA (β −7.069, SD 3.394, p < 0.05) were significant risk factors for eGFR reduction in men. CONCLUSION: The combined effect of dyslipidemia and high obesity indices is significantly related to the decline in eGFR. The association is more profound in men. Dove 2021-11-10 /pmc/articles/PMC8590978/ /pubmed/34785920 http://dx.doi.org/10.2147/DMSO.S337190 Text en © 2021 Wang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Wang, Xichang Wang, Haoyu Li, Jiashu Gao, Xiaotong Han, Yutong Teng, Weiping Shan, Zhongyan Lai, Yaxin Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population |
title | Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population |
title_full | Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population |
title_fullStr | Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population |
title_full_unstemmed | Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population |
title_short | Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population |
title_sort | combined effects of dyslipidemia and high adiposity on the estimated glomerular filtration rate in a middle-aged chinese population |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590978/ https://www.ncbi.nlm.nih.gov/pubmed/34785920 http://dx.doi.org/10.2147/DMSO.S337190 |
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