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Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China

PURPOSE: The main objective of this study was to decipher the general epidemiology, clinical characteristic, laboratory finding and chest computed tomography (CT) imaging features of the novel coronavirus disease (COVID-19) patients whose initial detection of severe acute respiratory syndrome corona...

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Autores principales: Liang, Yingjian, Zheng, Xiaobin, Chen, Meizhu, Tu, Changli, Tan, Cuiyan, Huang, Yiying, Wang, Zhenguo, Wu, Jian, Liu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590982/
https://www.ncbi.nlm.nih.gov/pubmed/34785946
http://dx.doi.org/10.2147/IJGM.S334301
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author Liang, Yingjian
Zheng, Xiaobin
Chen, Meizhu
Tu, Changli
Tan, Cuiyan
Huang, Yiying
Wang, Zhenguo
Wu, Jian
Liu, Jing
author_facet Liang, Yingjian
Zheng, Xiaobin
Chen, Meizhu
Tu, Changli
Tan, Cuiyan
Huang, Yiying
Wang, Zhenguo
Wu, Jian
Liu, Jing
author_sort Liang, Yingjian
collection PubMed
description PURPOSE: The main objective of this study was to decipher the general epidemiology, clinical characteristic, laboratory finding and chest computed tomography (CT) imaging features of the novel coronavirus disease (COVID-19) patients whose initial detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)is negative. METHODS: Nearly 100 confirmed cases admitted to The Fifth Affiliated Hospital of Sun Yat-sen University from 18th January to 26th February, 2020, were screened. Clinical records, laboratory results and CT images were reviewed for nine COVID-19 patients with initially negative RT-PCR detection. RESULTS: Fever and cough were common, and one patient merely present gastrointestinal symptoms. Increasing CRP and decreasing ALB were showed in nearly half of the patients among negative detection and return to normal level after real time polymerase chain reaction (RT-PCR) results converted from positive to negative. Left lower lobe was affected nearly in all the patients. A patient received oxygen support timely according his high Mulbsta score. CONCLUSION: Our study elucidated on the clinical features of hospitalized patients with initially negative detection of SARS-CoV nucleic acid. Patient merely with symptoms associated with digestive system should be screened for COVID-19. CT scan and repeated RT-PCR are two powerful diagnostic tools. Mulbsta score assessing in the early stage enhances the confidence of severity evaluation in physician.
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spelling pubmed-85909822021-11-15 Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China Liang, Yingjian Zheng, Xiaobin Chen, Meizhu Tu, Changli Tan, Cuiyan Huang, Yiying Wang, Zhenguo Wu, Jian Liu, Jing Int J Gen Med Original Research PURPOSE: The main objective of this study was to decipher the general epidemiology, clinical characteristic, laboratory finding and chest computed tomography (CT) imaging features of the novel coronavirus disease (COVID-19) patients whose initial detection of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)is negative. METHODS: Nearly 100 confirmed cases admitted to The Fifth Affiliated Hospital of Sun Yat-sen University from 18th January to 26th February, 2020, were screened. Clinical records, laboratory results and CT images were reviewed for nine COVID-19 patients with initially negative RT-PCR detection. RESULTS: Fever and cough were common, and one patient merely present gastrointestinal symptoms. Increasing CRP and decreasing ALB were showed in nearly half of the patients among negative detection and return to normal level after real time polymerase chain reaction (RT-PCR) results converted from positive to negative. Left lower lobe was affected nearly in all the patients. A patient received oxygen support timely according his high Mulbsta score. CONCLUSION: Our study elucidated on the clinical features of hospitalized patients with initially negative detection of SARS-CoV nucleic acid. Patient merely with symptoms associated with digestive system should be screened for COVID-19. CT scan and repeated RT-PCR are two powerful diagnostic tools. Mulbsta score assessing in the early stage enhances the confidence of severity evaluation in physician. Dove 2021-11-10 /pmc/articles/PMC8590982/ /pubmed/34785946 http://dx.doi.org/10.2147/IJGM.S334301 Text en © 2021 Liang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Liang, Yingjian
Zheng, Xiaobin
Chen, Meizhu
Tu, Changli
Tan, Cuiyan
Huang, Yiying
Wang, Zhenguo
Wu, Jian
Liu, Jing
Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
title Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
title_full Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
title_fullStr Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
title_full_unstemmed Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
title_short Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China
title_sort epidemiological, clinical, laboratorial and ct imaging features of hospitalized patients with initially negative detection of sars-cov-2 in china
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590982/
https://www.ncbi.nlm.nih.gov/pubmed/34785946
http://dx.doi.org/10.2147/IJGM.S334301
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