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Secondary Breast Cancer Sociodemographic Characteristics and Survival by Age Group

BACKGROUND: Secondary cancers account for 16% of all new cancer diagnoses, with breast cancer (BC) the most common secondary cancer. We have shown that secondary BC has unique characteristics and decreased survival compared with primary BC in adolescent and young adults (AYA; 15–39 years old). Howev...

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Autores principales: Sauder, Candice A. M., Li, Qian, Bold, Richard J., Ruddy, Kathryn J., Keegan, Theresa H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590999/
https://www.ncbi.nlm.nih.gov/pubmed/34185208
http://dx.doi.org/10.1245/s10434-021-10340-3
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author Sauder, Candice A. M.
Li, Qian
Bold, Richard J.
Ruddy, Kathryn J.
Keegan, Theresa H. M.
author_facet Sauder, Candice A. M.
Li, Qian
Bold, Richard J.
Ruddy, Kathryn J.
Keegan, Theresa H. M.
author_sort Sauder, Candice A. M.
collection PubMed
description BACKGROUND: Secondary cancers account for 16% of all new cancer diagnoses, with breast cancer (BC) the most common secondary cancer. We have shown that secondary BC has unique characteristics and decreased survival compared with primary BC in adolescent and young adults (AYA; 15–39 years old). However, older BC populations are less well studied. METHODS: Females (age ≥ 15 years) diagnosed with primary BC during 1991–2015 (n = 377,167) and enrolled in the California Cancer Registry were compared with those with secondary BC (n = 37,625) by age (15–39, 40–64, ≥ 65 years). We examined BC-specific survival (BCSS) accounting for other causes of death as a competing risk using multivariable Cox proportional hazards regression. RESULTS: Most secondary BC patients were of older age (15–39, n = 777; 40–64, n = 15,848; ≥ 65, n = 21,000). Compared with primary BC treatment, secondary BCs were more often treated with mastectomy and less often with chemotherapy and/or radiation. BCSS was shorter in secondary BC patients than primary BC patients, but the survival difference between secondary and primary BC diminished with age [15–39 hazard ratio (HR): 2.09, 95% confidence interval (CI) 1.83–2.39; 40–64 HR: 1.51; 95% CI 1.44–1.58; ≥ 65 HR: 1.14; 95% CI 1.10–1.19]. Survival differences were most pronounced in women with hormone receptor positive disease and Hispanic and Asian/Pacific Islanders 40–64 years of age. CONCLUSIONS: When BC is diagnosed following a prior cancer of any organ site, BCSS is worse than when compared with patients for whom BC is the primary diagnosis, suggesting that we may need to tailor our treatments for women with secondary BC.
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spelling pubmed-85909992021-11-23 Secondary Breast Cancer Sociodemographic Characteristics and Survival by Age Group Sauder, Candice A. M. Li, Qian Bold, Richard J. Ruddy, Kathryn J. Keegan, Theresa H. M. Ann Surg Oncol Global Health Services Research BACKGROUND: Secondary cancers account for 16% of all new cancer diagnoses, with breast cancer (BC) the most common secondary cancer. We have shown that secondary BC has unique characteristics and decreased survival compared with primary BC in adolescent and young adults (AYA; 15–39 years old). However, older BC populations are less well studied. METHODS: Females (age ≥ 15 years) diagnosed with primary BC during 1991–2015 (n = 377,167) and enrolled in the California Cancer Registry were compared with those with secondary BC (n = 37,625) by age (15–39, 40–64, ≥ 65 years). We examined BC-specific survival (BCSS) accounting for other causes of death as a competing risk using multivariable Cox proportional hazards regression. RESULTS: Most secondary BC patients were of older age (15–39, n = 777; 40–64, n = 15,848; ≥ 65, n = 21,000). Compared with primary BC treatment, secondary BCs were more often treated with mastectomy and less often with chemotherapy and/or radiation. BCSS was shorter in secondary BC patients than primary BC patients, but the survival difference between secondary and primary BC diminished with age [15–39 hazard ratio (HR): 2.09, 95% confidence interval (CI) 1.83–2.39; 40–64 HR: 1.51; 95% CI 1.44–1.58; ≥ 65 HR: 1.14; 95% CI 1.10–1.19]. Survival differences were most pronounced in women with hormone receptor positive disease and Hispanic and Asian/Pacific Islanders 40–64 years of age. CONCLUSIONS: When BC is diagnosed following a prior cancer of any organ site, BCSS is worse than when compared with patients for whom BC is the primary diagnosis, suggesting that we may need to tailor our treatments for women with secondary BC. Springer International Publishing 2021-06-29 2021 /pmc/articles/PMC8590999/ /pubmed/34185208 http://dx.doi.org/10.1245/s10434-021-10340-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Global Health Services Research
Sauder, Candice A. M.
Li, Qian
Bold, Richard J.
Ruddy, Kathryn J.
Keegan, Theresa H. M.
Secondary Breast Cancer Sociodemographic Characteristics and Survival by Age Group
title Secondary Breast Cancer Sociodemographic Characteristics and Survival by Age Group
title_full Secondary Breast Cancer Sociodemographic Characteristics and Survival by Age Group
title_fullStr Secondary Breast Cancer Sociodemographic Characteristics and Survival by Age Group
title_full_unstemmed Secondary Breast Cancer Sociodemographic Characteristics and Survival by Age Group
title_short Secondary Breast Cancer Sociodemographic Characteristics and Survival by Age Group
title_sort secondary breast cancer sociodemographic characteristics and survival by age group
topic Global Health Services Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590999/
https://www.ncbi.nlm.nih.gov/pubmed/34185208
http://dx.doi.org/10.1245/s10434-021-10340-3
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