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Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)

The capacity of the lethal Plasmodium falciparum parasite to develop resistance against anti-malarial drugs represents a central challenge in the global control and elimination of malaria. Historically, the action of drug transporters is known to play a pivotal role in the capacity of the parasite t...

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Autores principales: Gil, José Pedro, Fançony, Cláudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591188/
https://www.ncbi.nlm.nih.gov/pubmed/34790129
http://dx.doi.org/10.3389/fphar.2021.759422
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author Gil, José Pedro
Fançony, Cláudia
author_facet Gil, José Pedro
Fançony, Cláudia
author_sort Gil, José Pedro
collection PubMed
description The capacity of the lethal Plasmodium falciparum parasite to develop resistance against anti-malarial drugs represents a central challenge in the global control and elimination of malaria. Historically, the action of drug transporters is known to play a pivotal role in the capacity of the parasite to evade drug action. MRPs (Multidrug Resistance Protein) are known in many phylogenetically diverse groups to be related to drug resistance by being able to handle a large range of substrates, including important endogenous substances as glutathione and its conjugates. P. falciparum MRPs are associated with in vivo and in vitro altered drug response, and might be important factors for the development of multi-drug resistance phenotypes, a latent possibility in the present, and future, combination therapy environment. Information on P. falciparum MRPs is scattered in the literature, with no specialized review available. We herein address this issue by reviewing the present state of knowledge.
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spelling pubmed-85911882021-11-16 Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs) Gil, José Pedro Fançony, Cláudia Front Pharmacol Pharmacology The capacity of the lethal Plasmodium falciparum parasite to develop resistance against anti-malarial drugs represents a central challenge in the global control and elimination of malaria. Historically, the action of drug transporters is known to play a pivotal role in the capacity of the parasite to evade drug action. MRPs (Multidrug Resistance Protein) are known in many phylogenetically diverse groups to be related to drug resistance by being able to handle a large range of substrates, including important endogenous substances as glutathione and its conjugates. P. falciparum MRPs are associated with in vivo and in vitro altered drug response, and might be important factors for the development of multi-drug resistance phenotypes, a latent possibility in the present, and future, combination therapy environment. Information on P. falciparum MRPs is scattered in the literature, with no specialized review available. We herein address this issue by reviewing the present state of knowledge. Frontiers Media S.A. 2021-11-01 /pmc/articles/PMC8591188/ /pubmed/34790129 http://dx.doi.org/10.3389/fphar.2021.759422 Text en Copyright © 2021 Gil and Fançony. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Gil, José Pedro
Fançony, Cláudia
Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)
title Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)
title_full Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)
title_fullStr Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)
title_full_unstemmed Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)
title_short Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)
title_sort plasmodium falciparum multidrug resistance proteins (pfmrps)
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591188/
https://www.ncbi.nlm.nih.gov/pubmed/34790129
http://dx.doi.org/10.3389/fphar.2021.759422
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