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Therapeutic Suppression of FAK-AKT Signaling Overcomes Resistance to SHP2 Inhibition in Colorectal Carcinoma

SHP2 mediates signaling from multiple receptor tyrosine kinases (RTKs) to extracellular signal-regulated kinase (ERK) and Ser and Thr kinase AKT, and its inhibitors offer an unprecedented opportunity for cancer treatment. Although the ERK signaling variation after SHP2 inhibition has been well inves...

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Detalles Bibliográficos
Autores principales:	Li, Ye, Yuan, Yuncang, Zhang, Fan, Guo, Aizhen, Cao, Fuao, Song, Mengmeng, Fu, Yating, Xu, Xiaowen, Shen, Hao, Zheng, Shangyong, Pan, Yamin, Chang, Wenjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591248/ https://www.ncbi.nlm.nih.gov/pubmed/34790119 http://dx.doi.org/10.3389/fphar.2021.739501

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