Cargando…

High-Dose Betahistine Improves Cognitive Function in Patients With Schizophrenia: A Randomized Double-Blind Placebo-Controlled Trial

Background: There is currently no effective treatment for cognitive impairment associated with schizophrenia (CIAS). Recent studies have shown that increased histamine levels in the brain may help to improve CIAS symptoms. Betahistine is an H1-receptor agonist and H3-receptor antagonist. This study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yongqian, Huang, Xufeng, Fan, Hongzhen, An, Huimei, Ma, Ting, Zhang, Qi, Zhao, Wenxuan, Yun, Yajun, Yang, Wenshuang, Zhang, Xiaolu, Wang, Zhiren, Yang, Fude
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Psychiatry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591287/ https://www.ncbi.nlm.nih.gov/pubmed/34790138 http://dx.doi.org/10.3389/fpsyt.2021.762656

Ejemplares similares

Effects of Adjunctive Betahistine Therapy on Lipid Metabolism in Patients with Chronic Schizophrenia: A Randomized Double-Blind Placebo-Controlled Study
por: Bai, Luyuan, et al.
Publicado: (2023)

Relationship Between Plasma Olanzapine and N-Desmethyl-Olanzapine Concentration and Metabolic Parameters in Patients With Schizophrenia
por: An, Huimei, et al.
Publicado: (2022)

Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality
por: Zhang, Qi, et al.
Publicado: (2021)

Effects of smoking cessation on plasma clozapine concentrations in male patients with schizophrenia during the COVID-19 pandemic
por: Ma, Botao, et al.
Publicado: (2023)

Subcortical Brain Volumes Relate to Neurocognition in First-Episode Schizophrenia, Bipolar Disorder, Major Depression Disorder, and Healthy Controls
por: Shi, Jing, et al.
Publicado: (2022)

Effect of Betahistine and Metformin on Antipsychotic-Induced Weight Gain: An Analysis of Two Clinical Trials
por: Kang, Dongyu, et al.
Publicado: (2018)

Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia
por: Yang, Qingyan, et al.
Publicado: (2022)

Effects of Betahistine on Vestibulo-Ocular Reflex in Normal Healthy Adults: A Randomized Double-Blind, Placebo-Controlled Trial
por: Wan Hassan, Wan Ahmad Amiruddin, et al.
Publicado: (2022)

Vocal emotion perception in schizophrenia and its diagnostic significance
por: Zhao, Wenxuan, et al.
Publicado: (2023)

Alcohol drinking in male patients with chronic schizophrenia: prevalence and its relationship to clinical symptoms
por: Lv, Menghan, et al.
Publicado: (2023)

Paliperidone Extended-Release Tablets for the Treatment of Methamphetamine Use Disorder in Chinese Patients After Acute Treatment: A Randomized, Double-Blind, Placebo-Controlled Exploratory Study
por: Wang, Gang, et al.
Publicado: (2019)

Impaired Emotional Self-Referential Processing in First-Episode Schizophrenia
por: Zhao, Yanli, et al.
Publicado: (2021)

Efficacy and Safety of Intranasal Betahistine in the Treatment of Surgery-Induced Acute Vestibular Syndrome: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Study
por: Van de Heyning, Paul, et al.
Publicado: (2023)

Changes in energy during treatment of depression: an analysis of duloxetine in double-blind placebo-controlled trials
por: Harada, E, et al.
Publicado: (2015)

Which Subgroup of First-Episode Schizophrenia Patients Can Remit During the First Year of Antipsychotic Treatment?
por: Cheng, Zhang, et al.
Publicado: (2020)

Efficacy and safety of betahistine treatment in patients with Meniere’s disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial)
por: Adrion, Christine, et al.
Publicado: (2016)

Betahistine in the treatment of Ménière’s disease
por: Lacour, Michel, et al.
Publicado: (2007)

Mechanisms of Perceived Treatment Assignment and Subsequent Expectancy Effects in a Double Blind Placebo Controlled RCT of Major Depression
por: Laferton, Johannes A. C., et al.
Publicado: (2018)

Effects of High-Frequency rTMS on Negative Symptoms and Cognitive Function in Hospitalized Patients With Chronic Schizophrenia: A Double-Blind, Sham-Controlled Pilot Trial
por: Wen, Na, et al.
Publicado: (2021)

Repetitive transcranial magnetic stimulation for psychiatric symptoms in long-term hospitalized veterans with schizophrenia: A randomized double-blind controlled trial
por: Su, Xiuru, et al.
Publicado: (2022)

Resting-state functional connectivity of neural circuits associated with primary and secondary rewards in patients with bipolar disorder
por: Shi, Jing, et al.
Publicado: (2020)

Efficacy and Safety of Cordyceps militaris as an Adjuvant to Duloxetine in the Treatment of Insomnia in Patients With Depression: A 6-Week Double- Blind, Randomized, Placebo-Controlled Trial
por: Zhou, Jiaojiao, et al.
Publicado: (2021)

Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial
por: Ching, Terence H. W., et al.
Publicado: (2023)

A correlation study of intestinal microflora and first‐episode depression in Chinese patients and healthy volunteers
por: Zheng, Shaojun, et al.
Publicado: (2021)

Cortical Thickness in Alcohol Dependent Patients With Apathy
por: Yang, Kebing, et al.
Publicado: (2020)

Treatment of Vertigo: A Randomized, Double-Blind Trial Comparing Efficacy and Safety of Ginkgo biloba Extract EGb 761 and Betahistine
por: Sokolova, Larysa, et al.
Publicado: (2014)

Inverse Effects of Oxytocin on Attributing Mental Activity to Others in Depressed and Healthy Subjects: A Double-Blind Placebo Controlled fMRI Study
por: Pincus, David, et al.
Publicado: (2010)

Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Emotion, Cognition, and Attention: A Double-Blind, Placebo-Controlled, Randomized Experimental Trial in Healthy Volunteers
por: Woelfl, Timo, et al.
Publicado: (2020)

Commentary: A Randomized, Double-Blind, Placebo-Controlled Trial of Metformin Treatment of Weight Gain Associated with Initiation of Atypical Antipsychotic Therapy in Children and Adolescents
por: Goltz, Jeffrey Samuel, et al.
Publicado: (2017)

Effect of Methylphenidate on Resting-State Connectivity in Adolescents With a Disruptive Behavior Disorder: A Double-Blind Randomized Placebo-Controlled fMRI Study
por: Pape, Louise, et al.
Publicado: (2021)

Dual orexin receptor antagonists for treatment of insomnia: A systematic review and meta-analysis on randomized, double-blind, placebo-controlled trials of suvorexant and lemborexant
por: Khazaie, Habibolah, et al.
Publicado: (2022)

Can Daytime Transcranial Direct Current Stimulation Treatment Change the Sleep Electroencephalogram Complexity of REM Sleep in Depressed Patients? A Double-Blinded, Randomized, Placebo-Controlled Trial
por: Li, Zhe, et al.
Publicado: (2022)

The Role of Butyric Acid in Treatment Response in Drug-Naïve First Episode Schizophrenia
por: Li, Xue, et al.
Publicado: (2021)

Alterations in innate immune defense distinguish first-episode schizophrenia patients from healthy controls
por: Chen, Song, et al.
Publicado: (2022)

Spectrophotometric estimation of betahistine hydrochloride in tablet formulations
por: Kumar, Amit, et al.
Publicado: (2010)

Betahistine in the treatment of tinnitus in patients with vestibular disorders
por: Ganança, Maurício Malavasi, et al.
Publicado: (2015)

Abnormal amygdala subregional-sensorimotor connectivity correlates with positive symptom in schizophrenia
por: Zhang, Meng, et al.
Publicado: (2020)

Brain Stimulation and Group Therapy to Improve Gesture and Social Skills in Schizophrenia—The Study Protocol of a Randomized, Sham-Controlled, Three-Arm, Double-Blind Trial
por: Chapellier, Victoria, et al.
Publicado: (2022)

Insulin Resistance and Oxidative Stress: In Relation to Cognitive Function and Psychopathology in Drug-Naïve, First-Episode Drug-Free Schizophrenia
por: Tao, Qi, et al.
Publicado: (2020)

Omega-3 Fatty Acids as a Treatment for Pediatric Depression. A Phase III, 36 Weeks, Multi-Center, Double-Blind, Placebo-Controlled Randomized Superiority Study
por: Häberling, Isabelle, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_58688kl05qekup5sc5am3b6a9v