The sialidase NEU1 directly interacts with the juxtamembranous segment of the cytoplasmic domain of mucin-1 to inhibit downstream PI3K-Akt signaling

The extracellular domain (ED) of the membrane-spanning sialoglycoprotein, mucin-1 (MUC1), is an in vivo substrate for the lysosomal sialidase, neuraminidase-1 (NEU1). Engagement of the MUC1-ED by its cognate ligand, Pseudomonas aeruginosa-expressed flagellin, increases NEU1-MUC1 association and NEU1...

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Detalles Bibliográficos
Autores principales: Hyun, Sang W., Imamura, Akihiro, Ishida, Hideharu, Piepenbrink, Kurt H., Goldblum, Simeon E., Lillehoj, Erik P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591358/
https://www.ncbi.nlm.nih.gov/pubmed/34688655
http://dx.doi.org/10.1016/j.jbc.2021.101337

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