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Local and network-level dysregulation of error processing is associated with binge drinking

Binge drinking refers to the pattern of alcohol consumption that brings blood alcohol levels to or above legal intoxication levels. Commonly practiced by young adults, it is associated with neurofunctional alterations, raising health-related concerns. Executive deficits may contribute to the inabili...

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Autores principales: Alderson Myers, Austin B., Arienzo, Donatello, Molnar, Sean M., Marinkovic, Ksenija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591397/
https://www.ncbi.nlm.nih.gov/pubmed/34768146
http://dx.doi.org/10.1016/j.nicl.2021.102879
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author Alderson Myers, Austin B.
Arienzo, Donatello
Molnar, Sean M.
Marinkovic, Ksenija
author_facet Alderson Myers, Austin B.
Arienzo, Donatello
Molnar, Sean M.
Marinkovic, Ksenija
author_sort Alderson Myers, Austin B.
collection PubMed
description Binge drinking refers to the pattern of alcohol consumption that brings blood alcohol levels to or above legal intoxication levels. Commonly practiced by young adults, it is associated with neurofunctional alterations, raising health-related concerns. Executive deficits may contribute to the inability to refrain from excessive alcohol intake. As a facet of cognitive control, error processing allows for flexible modification of behavior to optimize future outcomes. It is highly relevant to addiction research, as a failure to inhibit excessive drinking results in relapses, which is a hallmark of alcohol use disorder. However, research on local and system-level neural underpinnings of inhibition failures as a function of binge drinking is limited. To address these gaps, functional magnetic resonance imaging (fMRI) was used to examine local changes and interregional functional connectivity during response inhibition errors on a Go/NoGo task. Young adult binge drinkers (BDs) performed equally well as light drinkers (LDs), a group of demographically matched individuals who drink regularly but in low-risk patterns. In contrast, BDs exhibited greater fMRI activity to inhibition errors contrasted with correct NoGo trials in the rostral anterior (rACC) and posterior cingulate cortices (PCC), as well as right middle frontal gyrus (R-MFG). Furthermore, BDs showed increased connectivity between the rACC and right lateral prefrontal cortex, in addition to greater connectivity between the R-MFG and the left ventrolateral and superior frontal cortices. Imaging indices were positively correlated only with alcohol-related measures, but not with those related to moods, disposition, or cognitive capacity. Taken together, greater error-related activity and expanded functional connectivity among prefrontal regions may serve a compensatory role to maintain efficiency of inhibitory control. Aligned with prominent models of addiction, these findings accentuate the importance of top-down control in maintaining low-risk drinking levels. They provide insight into potentially early signs of deteriorating cognitive control functions in BDs and may help guide intervention strategies aimed at preventing excessive drinking habits.
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spelling pubmed-85913972021-11-22 Local and network-level dysregulation of error processing is associated with binge drinking Alderson Myers, Austin B. Arienzo, Donatello Molnar, Sean M. Marinkovic, Ksenija Neuroimage Clin Regular Article Binge drinking refers to the pattern of alcohol consumption that brings blood alcohol levels to or above legal intoxication levels. Commonly practiced by young adults, it is associated with neurofunctional alterations, raising health-related concerns. Executive deficits may contribute to the inability to refrain from excessive alcohol intake. As a facet of cognitive control, error processing allows for flexible modification of behavior to optimize future outcomes. It is highly relevant to addiction research, as a failure to inhibit excessive drinking results in relapses, which is a hallmark of alcohol use disorder. However, research on local and system-level neural underpinnings of inhibition failures as a function of binge drinking is limited. To address these gaps, functional magnetic resonance imaging (fMRI) was used to examine local changes and interregional functional connectivity during response inhibition errors on a Go/NoGo task. Young adult binge drinkers (BDs) performed equally well as light drinkers (LDs), a group of demographically matched individuals who drink regularly but in low-risk patterns. In contrast, BDs exhibited greater fMRI activity to inhibition errors contrasted with correct NoGo trials in the rostral anterior (rACC) and posterior cingulate cortices (PCC), as well as right middle frontal gyrus (R-MFG). Furthermore, BDs showed increased connectivity between the rACC and right lateral prefrontal cortex, in addition to greater connectivity between the R-MFG and the left ventrolateral and superior frontal cortices. Imaging indices were positively correlated only with alcohol-related measures, but not with those related to moods, disposition, or cognitive capacity. Taken together, greater error-related activity and expanded functional connectivity among prefrontal regions may serve a compensatory role to maintain efficiency of inhibitory control. Aligned with prominent models of addiction, these findings accentuate the importance of top-down control in maintaining low-risk drinking levels. They provide insight into potentially early signs of deteriorating cognitive control functions in BDs and may help guide intervention strategies aimed at preventing excessive drinking habits. Elsevier 2021-11-09 /pmc/articles/PMC8591397/ /pubmed/34768146 http://dx.doi.org/10.1016/j.nicl.2021.102879 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Alderson Myers, Austin B.
Arienzo, Donatello
Molnar, Sean M.
Marinkovic, Ksenija
Local and network-level dysregulation of error processing is associated with binge drinking
title Local and network-level dysregulation of error processing is associated with binge drinking
title_full Local and network-level dysregulation of error processing is associated with binge drinking
title_fullStr Local and network-level dysregulation of error processing is associated with binge drinking
title_full_unstemmed Local and network-level dysregulation of error processing is associated with binge drinking
title_short Local and network-level dysregulation of error processing is associated with binge drinking
title_sort local and network-level dysregulation of error processing is associated with binge drinking
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591397/
https://www.ncbi.nlm.nih.gov/pubmed/34768146
http://dx.doi.org/10.1016/j.nicl.2021.102879
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