A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains

Positron emission tomography (PET) allows biomolecular tracking but PET monitoring of brain networks has been hampered by a lack of suitable reporters. Here, we take advantage of bacterial dihydrofolate reductase, ecDHFR, and its unique antagonist, TMP, to facilitate in vivo imaging in the brain. Pe...

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Detalles Bibliográficos
Autores principales: Shimojo, Masafumi, Ono, Maiko, Takuwa, Hiroyuki, Mimura, Koki, Nagai, Yuji, Fujinaga, Masayuki, Kikuchi, Tatsuya, Okada, Maki, Seki, Chie, Tokunaga, Masaki, Maeda, Jun, Takado, Yuhei, Takahashi, Manami, Minamihisamatsu, Takeharu, Zhang, Ming‐Rong, Tomita, Yutaka, Suzuki, Norihiro, Maximov, Anton, Suhara, Tetsuya, Minamimoto, Takafumi, Sahara, Naruhiko, Higuchi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591537/
https://www.ncbi.nlm.nih.gov/pubmed/34636430
http://dx.doi.org/10.15252/embj.2021107757

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