Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein–Protein Interactions

[Image: see text] We developed a new class of inhibitors of protein–protein interactions of the SHP2 phosphatase, which is pivotal in cell signaling and represents a central target in the therapy of cancer and rare diseases. Currently available SHP2 inhibitors target the catalytic site or an alloste...

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Detalles Bibliográficos
Autores principales: Bobone, Sara, Pannone, Luca, Biondi, Barbara, Solman, Maja, Flex, Elisabetta, Canale, Viviana Claudia, Calligari, Paolo, De Faveri, Chiara, Gandini, Tommaso, Quercioli, Andrea, Torini, Giuseppe, Venditti, Martina, Lauri, Antonella, Fasano, Giulia, Hoeksma, Jelmer, Santucci, Valerio, Cattani, Giada, Bocedi, Alessio, Carpentieri, Giovanna, Tirelli, Valentina, Sanchez, Massimo, Peggion, Cristina, Formaggio, Fernando, den Hertog, Jeroen, Martinelli, Simone, Bocchinfuso, Gianfranco, Tartaglia, Marco, Stella, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591604/
https://www.ncbi.nlm.nih.gov/pubmed/34714648
http://dx.doi.org/10.1021/acs.jmedchem.1c01371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591604/
https://www.ncbi.nlm.nih.gov/pubmed/34714648
http://dx.doi.org/10.1021/acs.jmedchem.1c01371

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