Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb

Pharmacologic interventions to halt/reverse the vascular remodeling and right ventricular dysfunction in pulmonary arterial hypertension (PAH) remains an unmet need. We previously demonstrated extracellular nicotinamide phosphoribosyltransferase (eNAMPT) as a DAMP (damage-associated molecular patter...

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Detalles Bibliográficos
Autores principales: Ahmed, Mohamed, Zaghloul, Nahla, Zimmerman, Prisca, Casanova, Nancy G., Sun, Xiaoguang, Song, Jin H., Hernon, Vivian Reyes, Sammani, Saad, Rischard, Franz, Rafikova, Olga, Rafikov, Ruslan, Makino, Ayako, Kempf, Carrie L., Camp, Sara M., Wang, Jian, Desai, Ankit A., Lussier, Yves, Yuan, Jason X.-J., Garcia, Joe G.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591779/
https://www.ncbi.nlm.nih.gov/pubmed/34790349
http://dx.doi.org/10.1177/20458940211059712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591779/
https://www.ncbi.nlm.nih.gov/pubmed/34790349
http://dx.doi.org/10.1177/20458940211059712

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