Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole

BACKGROUND: Mucormycosis is a rare fungal infection occurring chiefly in the lung or the rhino-orbital-cerebral compartment, particularly in patients with immunodeficiency or diabetes mellitus. Among Mucorales fungi, Rhizopus spp. are the most common cause of mucormycosis. CASE PRESENTATION: We repo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, F., Chen, J., Liu, F., Dang, Y. C., Kong, Q. T., Sang, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591890/
https://www.ncbi.nlm.nih.gov/pubmed/34775981
http://dx.doi.org/10.1186/s40001-021-00602-x
_version_ 1784599349843460096
author Yuan, F.
Chen, J.
Liu, F.
Dang, Y. C.
Kong, Q. T.
Sang, H.
author_facet Yuan, F.
Chen, J.
Liu, F.
Dang, Y. C.
Kong, Q. T.
Sang, H.
author_sort Yuan, F.
collection PubMed
description BACKGROUND: Mucormycosis is a rare fungal infection occurring chiefly in the lung or the rhino-orbital-cerebral compartment, particularly in patients with immunodeficiency or diabetes mellitus. Among Mucorales fungi, Rhizopus spp. are the most common cause of mucormycosis. CASE PRESENTATION: We report a case of pulmonary mucormycosis caused by Rhizopus microsporus in a young patient with diabetes but no other apparent risk factors. The diagnosis mainly relied on clinical manifestation, positive pulmonary tissue biopsy, and fungal culture. The patient was successfully treated with posaconazole oral suspension and remains asymptomatic at one-year follow-up. CONCLUSIONS: Pulmonary mucormycosis is a life-threatening condition and posaconazole is an effective treatment for pulmonary mucormycosis caused by Rhizopus microspores.
format Online
Article
Text
id pubmed-8591890
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-85918902021-11-15 Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole Yuan, F. Chen, J. Liu, F. Dang, Y. C. Kong, Q. T. Sang, H. Eur J Med Res Case Report BACKGROUND: Mucormycosis is a rare fungal infection occurring chiefly in the lung or the rhino-orbital-cerebral compartment, particularly in patients with immunodeficiency or diabetes mellitus. Among Mucorales fungi, Rhizopus spp. are the most common cause of mucormycosis. CASE PRESENTATION: We report a case of pulmonary mucormycosis caused by Rhizopus microsporus in a young patient with diabetes but no other apparent risk factors. The diagnosis mainly relied on clinical manifestation, positive pulmonary tissue biopsy, and fungal culture. The patient was successfully treated with posaconazole oral suspension and remains asymptomatic at one-year follow-up. CONCLUSIONS: Pulmonary mucormycosis is a life-threatening condition and posaconazole is an effective treatment for pulmonary mucormycosis caused by Rhizopus microspores. BioMed Central 2021-11-14 /pmc/articles/PMC8591890/ /pubmed/34775981 http://dx.doi.org/10.1186/s40001-021-00602-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Yuan, F.
Chen, J.
Liu, F.
Dang, Y. C.
Kong, Q. T.
Sang, H.
Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole
title Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole
title_full Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole
title_fullStr Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole
title_full_unstemmed Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole
title_short Successful treatment of pulmonary mucormycosis caused by Rhizopus microsporus with posaconazole
title_sort successful treatment of pulmonary mucormycosis caused by rhizopus microsporus with posaconazole
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591890/
https://www.ncbi.nlm.nih.gov/pubmed/34775981
http://dx.doi.org/10.1186/s40001-021-00602-x
work_keys_str_mv AT yuanf successfultreatmentofpulmonarymucormycosiscausedbyrhizopusmicrosporuswithposaconazole
AT chenj successfultreatmentofpulmonarymucormycosiscausedbyrhizopusmicrosporuswithposaconazole
AT liuf successfultreatmentofpulmonarymucormycosiscausedbyrhizopusmicrosporuswithposaconazole
AT dangyc successfultreatmentofpulmonarymucormycosiscausedbyrhizopusmicrosporuswithposaconazole
AT kongqt successfultreatmentofpulmonarymucormycosiscausedbyrhizopusmicrosporuswithposaconazole
AT sangh successfultreatmentofpulmonarymucormycosiscausedbyrhizopusmicrosporuswithposaconazole

Ejemplares similares