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Avoidance memory requires CaMKII activity to persist after recall

Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement...

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Detalles Bibliográficos
Autores principales: Radiske, Andressa, Gonzalez, Maria Carolina, Rossato, Janine I., Apolinário, Gênedy, de Oliveira, João R., Bevilaqua, Lia R. M., Cammarota, Martín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591931/
https://www.ncbi.nlm.nih.gov/pubmed/34775982
http://dx.doi.org/10.1186/s13041-021-00877-5
Descripción
Sumario:Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13041-021-00877-5.