Avoidance memory requires CaMKII activity to persist after recall

Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement...

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Autores principales: Radiske, Andressa, Gonzalez, Maria Carolina, Rossato, Janine I., Apolinário, Gênedy, de Oliveira, João R., Bevilaqua, Lia R. M., Cammarota, Martín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Micro Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591931/
https://www.ncbi.nlm.nih.gov/pubmed/34775982
http://dx.doi.org/10.1186/s13041-021-00877-5
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author Radiske, Andressa
Gonzalez, Maria Carolina
Rossato, Janine I.
Apolinário, Gênedy
de Oliveira, João R.
Bevilaqua, Lia R. M.
Cammarota, Martín
author_facet Radiske, Andressa
Gonzalez, Maria Carolina
Rossato, Janine I.
Apolinário, Gênedy
de Oliveira, João R.
Bevilaqua, Lia R. M.
Cammarota, Martín
author_sort Radiske, Andressa
collection PubMed
description Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13041-021-00877-5.
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spelling pubmed-85919312021-11-15 Avoidance memory requires CaMKII activity to persist after recall Radiske, Andressa Gonzalez, Maria Carolina Rossato, Janine I. Apolinário, Gênedy de Oliveira, João R. Bevilaqua, Lia R. M. Cammarota, Martín Mol Brain Micro Report Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13041-021-00877-5. BioMed Central 2021-11-14 /pmc/articles/PMC8591931/ /pubmed/34775982 http://dx.doi.org/10.1186/s13041-021-00877-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Micro Report
Radiske, Andressa
Gonzalez, Maria Carolina
Rossato, Janine I.
Apolinário, Gênedy
de Oliveira, João R.
Bevilaqua, Lia R. M.
Cammarota, Martín
Avoidance memory requires CaMKII activity to persist after recall
title Avoidance memory requires CaMKII activity to persist after recall
title_full Avoidance memory requires CaMKII activity to persist after recall
title_fullStr Avoidance memory requires CaMKII activity to persist after recall
title_full_unstemmed Avoidance memory requires CaMKII activity to persist after recall
title_short Avoidance memory requires CaMKII activity to persist after recall
title_sort avoidance memory requires camkii activity to persist after recall
topic Micro Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591931/
https://www.ncbi.nlm.nih.gov/pubmed/34775982
http://dx.doi.org/10.1186/s13041-021-00877-5
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