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Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk

Antibodies to phospholipids (aPL) and associated proteins are a hallmark in the diagnosis of anti-phospholipid syndrome (APS). Those included in the classification criteria are the lupus anticoagulant (LA) and the IgG and IgM isotypes of anticardiolipin (aCL) and anti-beta-2 glycoprotein I (β2GPI) a...

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Autores principales: Egri, Natalia, Bentow, Chelsea, Rubio, Laura, Norman, Gary L., López-Sañudo, Susana, Mahler, Michael, Pérez-Isidro, Albert, Cervera, Ricard, Viñas, Odette, Espinosa, Gerard, Ruiz-Ortiz, Estíbaliz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592011/
https://www.ncbi.nlm.nih.gov/pubmed/34790198
http://dx.doi.org/10.3389/fimmu.2021.754469
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author Egri, Natalia
Bentow, Chelsea
Rubio, Laura
Norman, Gary L.
López-Sañudo, Susana
Mahler, Michael
Pérez-Isidro, Albert
Cervera, Ricard
Viñas, Odette
Espinosa, Gerard
Ruiz-Ortiz, Estíbaliz
author_facet Egri, Natalia
Bentow, Chelsea
Rubio, Laura
Norman, Gary L.
López-Sañudo, Susana
Mahler, Michael
Pérez-Isidro, Albert
Cervera, Ricard
Viñas, Odette
Espinosa, Gerard
Ruiz-Ortiz, Estíbaliz
author_sort Egri, Natalia
collection PubMed
description Antibodies to phospholipids (aPL) and associated proteins are a hallmark in the diagnosis of anti-phospholipid syndrome (APS). Those included in the classification criteria are the lupus anticoagulant (LA) and the IgG and IgM isotypes of anticardiolipin (aCL) and anti-beta-2 glycoprotein I (β2GPI) antibodies. Non-classification criteria markers such as autoantibodies that recognize the phosphatidylserine/prothrombin (aPS/PT) complex have been proposed as biomarkers for APS. Studies of aPS/PT antibodies have shown a strong correlation to clinical manifestations and LA. We aimed to study the value and the persistence of aPS/PT IgG and IgM antibodies in a cohort of consecutive patients with clinical suspicion of APS and their utility as thrombotic risk markers. Our study, with 103 patients, demonstrates that persistently positive results for aPS/PT IgG antibodies were significantly associated with APS classification, thrombosis, triple aPL positivity, LA positive result, and the Global APS Score (GAPSS) > than 9 points (p < 0.01, for each condition). On the other hand, no association was seen with pregnancy morbidity (p = 0.56) and SLE (p = 0.07). Persistence of aPS/PT antibodies, defined according to the current laboratory classification criteria, likely improves the diagnosis and clinical assessment of patients with APS.
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spelling pubmed-85920112021-11-16 Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk Egri, Natalia Bentow, Chelsea Rubio, Laura Norman, Gary L. López-Sañudo, Susana Mahler, Michael Pérez-Isidro, Albert Cervera, Ricard Viñas, Odette Espinosa, Gerard Ruiz-Ortiz, Estíbaliz Front Immunol Immunology Antibodies to phospholipids (aPL) and associated proteins are a hallmark in the diagnosis of anti-phospholipid syndrome (APS). Those included in the classification criteria are the lupus anticoagulant (LA) and the IgG and IgM isotypes of anticardiolipin (aCL) and anti-beta-2 glycoprotein I (β2GPI) antibodies. Non-classification criteria markers such as autoantibodies that recognize the phosphatidylserine/prothrombin (aPS/PT) complex have been proposed as biomarkers for APS. Studies of aPS/PT antibodies have shown a strong correlation to clinical manifestations and LA. We aimed to study the value and the persistence of aPS/PT IgG and IgM antibodies in a cohort of consecutive patients with clinical suspicion of APS and their utility as thrombotic risk markers. Our study, with 103 patients, demonstrates that persistently positive results for aPS/PT IgG antibodies were significantly associated with APS classification, thrombosis, triple aPL positivity, LA positive result, and the Global APS Score (GAPSS) > than 9 points (p < 0.01, for each condition). On the other hand, no association was seen with pregnancy morbidity (p = 0.56) and SLE (p = 0.07). Persistence of aPS/PT antibodies, defined according to the current laboratory classification criteria, likely improves the diagnosis and clinical assessment of patients with APS. Frontiers Media S.A. 2021-10-21 /pmc/articles/PMC8592011/ /pubmed/34790198 http://dx.doi.org/10.3389/fimmu.2021.754469 Text en Copyright © 2021 Egri, Bentow, Rubio, Norman, López-Sañudo, Mahler, Pérez-Isidro, Cervera, Viñas, Espinosa and Ruiz-Ortiz https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Egri, Natalia
Bentow, Chelsea
Rubio, Laura
Norman, Gary L.
López-Sañudo, Susana
Mahler, Michael
Pérez-Isidro, Albert
Cervera, Ricard
Viñas, Odette
Espinosa, Gerard
Ruiz-Ortiz, Estíbaliz
Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk
title Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk
title_full Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk
title_fullStr Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk
title_full_unstemmed Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk
title_short Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk
title_sort anti-phosphatidylserine/prothrombin antibodies at two points: correlation with lupus anticoagulant and thrombotic risk
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592011/
https://www.ncbi.nlm.nih.gov/pubmed/34790198
http://dx.doi.org/10.3389/fimmu.2021.754469
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