Structure-Guided Design of d-Galactal Derivatives with High Affinity and Selectivity for the Galectin-8 N-Terminal Domain

[Image: see text] Galectin-8 is a carbohydrate-binding protein that plays a crucial role in tumor progression and metastasis, antibacterial autophagy, modulation of the immune system, and bone remodeling. The design, synthesis, and protein affinity evaluation of a set of C-3 substituted benzimidazol...

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Detalles Bibliográficos
Autores principales: Hassan, Mujtaba, Baussière, Floriane, Guzelj, Samo, Sundin, Anders P., Håkansson, Maria, Kovačič, Rebeka, Leffler, Hakon, Tomašič, Tihomir, Anderluh, Marko, Jakopin, Žiga, Nilsson, Ulf J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592027/
https://www.ncbi.nlm.nih.gov/pubmed/34795863
http://dx.doi.org/10.1021/acsmedchemlett.1c00371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592027/
https://www.ncbi.nlm.nih.gov/pubmed/34795863
http://dx.doi.org/10.1021/acsmedchemlett.1c00371

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