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Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
Preeclampsia is both a vascular and inflammatory disorder. Since the placenta is a conduit for fetal development, preeclampsia should be a presumed cause of adverse infant outcomes. Yet, the relationship of placental pathology, inflammation and neurological outcomes after preeclampsia are understudi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592443/ https://www.ncbi.nlm.nih.gov/pubmed/34780565 http://dx.doi.org/10.1371/journal.pone.0260094 |
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author | Sotiros, Alexandra Thornhill, Dianne Post, Miriam D. Winn, Virginia D. Armstrong, Jennifer |
author_facet | Sotiros, Alexandra Thornhill, Dianne Post, Miriam D. Winn, Virginia D. Armstrong, Jennifer |
author_sort | Sotiros, Alexandra |
collection | PubMed |
description | Preeclampsia is both a vascular and inflammatory disorder. Since the placenta is a conduit for fetal development, preeclampsia should be a presumed cause of adverse infant outcomes. Yet, the relationship of placental pathology, inflammation and neurological outcomes after preeclampsia are understudied. We prospectively examined a cohort of maternal-infant dyads with preeclampsia for maternal inflammatory cytokines at time of preeclampsia diagnosis and delivery, and fetal cord blood cytokines (IL-1β, IL-6, IL-8, and TNF-α). Placentas were analyzed for inflammatory and vascular pathologies. Neurodevelopmental assessment of infants utilizing the Pediatric Stroke Outcome Measure (PSOM) was conducted at 6-month corrected gestational age. Eighty-one maternal-newborn dyads were examined. Worse neurological outcomes were not associated with elevated maternal / fetal cytokines. Early preterm birth (gestational age ≤ 32 weeks) was associated with worse neurological outcomes at 6-months regardless of maternal/ fetal cytokine levels, placental pathology, or cranial ultrasound findings (OR 1.70, [1.16–2.48], p = 0.006). When correcting for gestational age, elevated IL-6 approached significance as a predictor for worse developmental outcome (OR 1.025 [0.985–1.066], p = 0.221). Pathological evidence of maternal malperfusion and worse outcomes were noted in early preterm, although our sample size was small. Our study did not demonstrate an obvious association of inflammation and placental pathology in preeclampsia and adverse neurodevelopmental outcome at 6-month corrected age but does suggest maternal malperfusion at earlier gestational age may be a risk factor for worse outcome. |
format | Online Article Text |
id | pubmed-8592443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-85924432021-11-16 Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers Sotiros, Alexandra Thornhill, Dianne Post, Miriam D. Winn, Virginia D. Armstrong, Jennifer PLoS One Research Article Preeclampsia is both a vascular and inflammatory disorder. Since the placenta is a conduit for fetal development, preeclampsia should be a presumed cause of adverse infant outcomes. Yet, the relationship of placental pathology, inflammation and neurological outcomes after preeclampsia are understudied. We prospectively examined a cohort of maternal-infant dyads with preeclampsia for maternal inflammatory cytokines at time of preeclampsia diagnosis and delivery, and fetal cord blood cytokines (IL-1β, IL-6, IL-8, and TNF-α). Placentas were analyzed for inflammatory and vascular pathologies. Neurodevelopmental assessment of infants utilizing the Pediatric Stroke Outcome Measure (PSOM) was conducted at 6-month corrected gestational age. Eighty-one maternal-newborn dyads were examined. Worse neurological outcomes were not associated with elevated maternal / fetal cytokines. Early preterm birth (gestational age ≤ 32 weeks) was associated with worse neurological outcomes at 6-months regardless of maternal/ fetal cytokine levels, placental pathology, or cranial ultrasound findings (OR 1.70, [1.16–2.48], p = 0.006). When correcting for gestational age, elevated IL-6 approached significance as a predictor for worse developmental outcome (OR 1.025 [0.985–1.066], p = 0.221). Pathological evidence of maternal malperfusion and worse outcomes were noted in early preterm, although our sample size was small. Our study did not demonstrate an obvious association of inflammation and placental pathology in preeclampsia and adverse neurodevelopmental outcome at 6-month corrected age but does suggest maternal malperfusion at earlier gestational age may be a risk factor for worse outcome. Public Library of Science 2021-11-15 /pmc/articles/PMC8592443/ /pubmed/34780565 http://dx.doi.org/10.1371/journal.pone.0260094 Text en © 2021 Sotiros et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sotiros, Alexandra Thornhill, Dianne Post, Miriam D. Winn, Virginia D. Armstrong, Jennifer Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers |
title | Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers |
title_full | Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers |
title_fullStr | Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers |
title_full_unstemmed | Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers |
title_short | Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers |
title_sort | inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592443/ https://www.ncbi.nlm.nih.gov/pubmed/34780565 http://dx.doi.org/10.1371/journal.pone.0260094 |
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