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Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers

Preeclampsia is both a vascular and inflammatory disorder. Since the placenta is a conduit for fetal development, preeclampsia should be a presumed cause of adverse infant outcomes. Yet, the relationship of placental pathology, inflammation and neurological outcomes after preeclampsia are understudi...

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Autores principales: Sotiros, Alexandra, Thornhill, Dianne, Post, Miriam D., Winn, Virginia D., Armstrong, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592443/
https://www.ncbi.nlm.nih.gov/pubmed/34780565
http://dx.doi.org/10.1371/journal.pone.0260094
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author Sotiros, Alexandra
Thornhill, Dianne
Post, Miriam D.
Winn, Virginia D.
Armstrong, Jennifer
author_facet Sotiros, Alexandra
Thornhill, Dianne
Post, Miriam D.
Winn, Virginia D.
Armstrong, Jennifer
author_sort Sotiros, Alexandra
collection PubMed
description Preeclampsia is both a vascular and inflammatory disorder. Since the placenta is a conduit for fetal development, preeclampsia should be a presumed cause of adverse infant outcomes. Yet, the relationship of placental pathology, inflammation and neurological outcomes after preeclampsia are understudied. We prospectively examined a cohort of maternal-infant dyads with preeclampsia for maternal inflammatory cytokines at time of preeclampsia diagnosis and delivery, and fetal cord blood cytokines (IL-1β, IL-6, IL-8, and TNF-α). Placentas were analyzed for inflammatory and vascular pathologies. Neurodevelopmental assessment of infants utilizing the Pediatric Stroke Outcome Measure (PSOM) was conducted at 6-month corrected gestational age. Eighty-one maternal-newborn dyads were examined. Worse neurological outcomes were not associated with elevated maternal / fetal cytokines. Early preterm birth (gestational age ≤ 32 weeks) was associated with worse neurological outcomes at 6-months regardless of maternal/ fetal cytokine levels, placental pathology, or cranial ultrasound findings (OR 1.70, [1.16–2.48], p = 0.006). When correcting for gestational age, elevated IL-6 approached significance as a predictor for worse developmental outcome (OR 1.025 [0.985–1.066], p = 0.221). Pathological evidence of maternal malperfusion and worse outcomes were noted in early preterm, although our sample size was small. Our study did not demonstrate an obvious association of inflammation and placental pathology in preeclampsia and adverse neurodevelopmental outcome at 6-month corrected age but does suggest maternal malperfusion at earlier gestational age may be a risk factor for worse outcome.
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spelling pubmed-85924432021-11-16 Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers Sotiros, Alexandra Thornhill, Dianne Post, Miriam D. Winn, Virginia D. Armstrong, Jennifer PLoS One Research Article Preeclampsia is both a vascular and inflammatory disorder. Since the placenta is a conduit for fetal development, preeclampsia should be a presumed cause of adverse infant outcomes. Yet, the relationship of placental pathology, inflammation and neurological outcomes after preeclampsia are understudied. We prospectively examined a cohort of maternal-infant dyads with preeclampsia for maternal inflammatory cytokines at time of preeclampsia diagnosis and delivery, and fetal cord blood cytokines (IL-1β, IL-6, IL-8, and TNF-α). Placentas were analyzed for inflammatory and vascular pathologies. Neurodevelopmental assessment of infants utilizing the Pediatric Stroke Outcome Measure (PSOM) was conducted at 6-month corrected gestational age. Eighty-one maternal-newborn dyads were examined. Worse neurological outcomes were not associated with elevated maternal / fetal cytokines. Early preterm birth (gestational age ≤ 32 weeks) was associated with worse neurological outcomes at 6-months regardless of maternal/ fetal cytokine levels, placental pathology, or cranial ultrasound findings (OR 1.70, [1.16–2.48], p = 0.006). When correcting for gestational age, elevated IL-6 approached significance as a predictor for worse developmental outcome (OR 1.025 [0.985–1.066], p = 0.221). Pathological evidence of maternal malperfusion and worse outcomes were noted in early preterm, although our sample size was small. Our study did not demonstrate an obvious association of inflammation and placental pathology in preeclampsia and adverse neurodevelopmental outcome at 6-month corrected age but does suggest maternal malperfusion at earlier gestational age may be a risk factor for worse outcome. Public Library of Science 2021-11-15 /pmc/articles/PMC8592443/ /pubmed/34780565 http://dx.doi.org/10.1371/journal.pone.0260094 Text en © 2021 Sotiros et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sotiros, Alexandra
Thornhill, Dianne
Post, Miriam D.
Winn, Virginia D.
Armstrong, Jennifer
Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
title Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
title_full Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
title_fullStr Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
title_full_unstemmed Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
title_short Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
title_sort inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592443/
https://www.ncbi.nlm.nih.gov/pubmed/34780565
http://dx.doi.org/10.1371/journal.pone.0260094
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