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A modified weighted log-rank test for confirmatory trials with a high proportion of treatment switching
In confirmatory cancer clinical trials, overall survival (OS) is normally a primary endpoint in the intention-to-treat (ITT) analysis under regulatory standards. After the tumor progresses, it is common that patients allocated to the control group switch to the experimental treatment, or another dru...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592474/ https://www.ncbi.nlm.nih.gov/pubmed/34780488 http://dx.doi.org/10.1371/journal.pone.0259178 |