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ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations

ModVizPop is an interactive and dynamic visualization tool developed for simulating differential equation–based population pharmacokinetic (PK) and pharmacodynamic (PD) models with variability. It has a built‐in PK/PD ordinary differential equations library of models to choose from alongside the abi...

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Detalles Bibliográficos
Autores principales: Vaddady, Pavan, Kandala, Bhargava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592511/
https://www.ncbi.nlm.nih.gov/pubmed/34319009
http://dx.doi.org/10.1002/psp4.12697
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author Vaddady, Pavan
Kandala, Bhargava
author_facet Vaddady, Pavan
Kandala, Bhargava
author_sort Vaddady, Pavan
collection PubMed
description ModVizPop is an interactive and dynamic visualization tool developed for simulating differential equation–based population pharmacokinetic (PK) and pharmacodynamic (PD) models with variability. It has a built‐in PK/PD ordinary differential equations library of models to choose from alongside the ability to plug in a user‐defined model from a local or project directory. The user interface consists of several key inputs for performing the simulations as well as options to visualize the plots, perform simple noncompartmental analysis, and review inputs and model code. It also provides the ability to download the underlying model, plots, simulated data, or a comprehensive report consisting of all the key inputs and outputs of the simulations. The interface includes advanced features where users can overlay external data on a simulation, set a certain simulation scenario as a reference, or carry out sensitivity analysis–based simulations. This easy‐to‐use interface can serve as a valuable tool to project teams to evaluate potential scenarios facilitating collaborative decision making in the drug discovery and development paradigm.
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spelling pubmed-85925112021-11-22 ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations Vaddady, Pavan Kandala, Bhargava CPT Pharmacometrics Syst Pharmacol Tutorials ModVizPop is an interactive and dynamic visualization tool developed for simulating differential equation–based population pharmacokinetic (PK) and pharmacodynamic (PD) models with variability. It has a built‐in PK/PD ordinary differential equations library of models to choose from alongside the ability to plug in a user‐defined model from a local or project directory. The user interface consists of several key inputs for performing the simulations as well as options to visualize the plots, perform simple noncompartmental analysis, and review inputs and model code. It also provides the ability to download the underlying model, plots, simulated data, or a comprehensive report consisting of all the key inputs and outputs of the simulations. The interface includes advanced features where users can overlay external data on a simulation, set a certain simulation scenario as a reference, or carry out sensitivity analysis–based simulations. This easy‐to‐use interface can serve as a valuable tool to project teams to evaluate potential scenarios facilitating collaborative decision making in the drug discovery and development paradigm. John Wiley and Sons Inc. 2021-08-21 2021-11 /pmc/articles/PMC8592511/ /pubmed/34319009 http://dx.doi.org/10.1002/psp4.12697 Text en © 2021 Merck Sharp & Dohme Corp. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Tutorials
Vaddady, Pavan
Kandala, Bhargava
ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
title ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
title_full ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
title_fullStr ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
title_full_unstemmed ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
title_short ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
title_sort modvizpop: a shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
topic Tutorials
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592511/
https://www.ncbi.nlm.nih.gov/pubmed/34319009
http://dx.doi.org/10.1002/psp4.12697
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