Enhanced oral bioavailability of koumine by complexation with hydroxypropyl-β-cyclodextrin: preparation, optimization, ex vivo and in vivo characterization

Koumine (KME) is an active alkaloid extracted from Gelsemium elegans, and its diverse bioactivities have been studied for decades. However, KME exhibits poor solubility and low oral bioavailability, which hampers its potential therapeutic exploitation. This work aimed to develop optimized inclusion...

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Detalles Bibliográficos
Autores principales: Hu, Qing, Fu, Xiaoling, Su, Yanping, Wang, Yanfang, Gao, Sihuan, Wang, Xiaoqin, Xu, Ying, Yu, Changxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592623/
https://www.ncbi.nlm.nih.gov/pubmed/34763595
http://dx.doi.org/10.1080/10717544.2021.1998248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592623/
https://www.ncbi.nlm.nih.gov/pubmed/34763595
http://dx.doi.org/10.1080/10717544.2021.1998248

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