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Atypical Histological Features as Risk Factors for Recurrence in Newly Diagnosed WHO Grade I Meningioma
The significance of atypical histological features (AHF) as risk factors for recurrence in benign meningioma is not well understood. This study examined risk factors of World Health Organization (WHO) Grade I meningioma (GIM) recurrence, focusing on AHF. We investigated 150 consecutive newly diagnos...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Japan Neurosurgical Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592816/ https://www.ncbi.nlm.nih.gov/pubmed/34470989 http://dx.doi.org/10.2176/nmc.oa.2021-0153 |
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author | CHIBA, Keitaro SUGAWARA, Takashi KOBAYASHI, Daisuke SATO, Akihito MUROTA, Yasuhiro MAEHARA, Taketoshi |
author_facet | CHIBA, Keitaro SUGAWARA, Takashi KOBAYASHI, Daisuke SATO, Akihito MUROTA, Yasuhiro MAEHARA, Taketoshi |
author_sort | CHIBA, Keitaro |
collection | PubMed |
description | The significance of atypical histological features (AHF) as risk factors for recurrence in benign meningioma is not well understood. This study examined risk factors of World Health Organization (WHO) Grade I meningioma (GIM) recurrence, focusing on AHF. We investigated 150 consecutive newly diagnosed GIM patients who had more than one year of follow-up after resection in our hospital between January 2007 and March 2018. The following factors were reviewed retrospectively: age, sex, tumor location, extent of resection, MIB-1 index, mitotic figures, number and distribution of AHF, and recurrence. The patients were grouped according to the presence or absence of recurrence and comparatively examined. Recurrence was observed in 10 cases (6.7%). Univariate analysis showed that patients with recurrence had a significantly higher MIB-1 index (2.0 vs. 4.3; p = 0.006) and a significantly higher proportion of male patients (21.4% vs. 70.0%; p = 0.002) and patients with sheet-like growth (6.42% vs. 30.0%; p = 0.04). In multivariate analysis, skull base location (odds ratio [OR] 31.424; 95% confidence interval [CI] 1.74–569), gross total resection (OR 0.130; 95% CI 0.0189–0.897), and MIB-1 index (OR 1.939; 95% CI 1.19–3.15) were significantly associated with recurrence. Our study revealed that skull base location, subtotal resection, and high MIB-1 index were independent risk factors for recurrence. Only the presence of sheet-like growth had a significantly higher incidence in patients with recurrence in univariate analysis of AHF. Multivariate analysis found no significant association. Sheet-like growth may be involved in malignancy and recurrence of benign meningioma. |
format | Online Article Text |
id | pubmed-8592816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japan Neurosurgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-85928162021-11-19 Atypical Histological Features as Risk Factors for Recurrence in Newly Diagnosed WHO Grade I Meningioma CHIBA, Keitaro SUGAWARA, Takashi KOBAYASHI, Daisuke SATO, Akihito MUROTA, Yasuhiro MAEHARA, Taketoshi Neurol Med Chir (Tokyo) Original Article The significance of atypical histological features (AHF) as risk factors for recurrence in benign meningioma is not well understood. This study examined risk factors of World Health Organization (WHO) Grade I meningioma (GIM) recurrence, focusing on AHF. We investigated 150 consecutive newly diagnosed GIM patients who had more than one year of follow-up after resection in our hospital between January 2007 and March 2018. The following factors were reviewed retrospectively: age, sex, tumor location, extent of resection, MIB-1 index, mitotic figures, number and distribution of AHF, and recurrence. The patients were grouped according to the presence or absence of recurrence and comparatively examined. Recurrence was observed in 10 cases (6.7%). Univariate analysis showed that patients with recurrence had a significantly higher MIB-1 index (2.0 vs. 4.3; p = 0.006) and a significantly higher proportion of male patients (21.4% vs. 70.0%; p = 0.002) and patients with sheet-like growth (6.42% vs. 30.0%; p = 0.04). In multivariate analysis, skull base location (odds ratio [OR] 31.424; 95% confidence interval [CI] 1.74–569), gross total resection (OR 0.130; 95% CI 0.0189–0.897), and MIB-1 index (OR 1.939; 95% CI 1.19–3.15) were significantly associated with recurrence. Our study revealed that skull base location, subtotal resection, and high MIB-1 index were independent risk factors for recurrence. Only the presence of sheet-like growth had a significantly higher incidence in patients with recurrence in univariate analysis of AHF. Multivariate analysis found no significant association. Sheet-like growth may be involved in malignancy and recurrence of benign meningioma. The Japan Neurosurgical Society 2021-11 2021-09-01 /pmc/articles/PMC8592816/ /pubmed/34470989 http://dx.doi.org/10.2176/nmc.oa.2021-0153 Text en © 2021 The Japan Neurosurgical Society https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Original Article CHIBA, Keitaro SUGAWARA, Takashi KOBAYASHI, Daisuke SATO, Akihito MUROTA, Yasuhiro MAEHARA, Taketoshi Atypical Histological Features as Risk Factors for Recurrence in Newly Diagnosed WHO Grade I Meningioma |
title | Atypical Histological Features as Risk Factors for Recurrence in Newly Diagnosed WHO Grade I Meningioma |
title_full | Atypical Histological Features as Risk Factors for Recurrence in Newly Diagnosed WHO Grade I Meningioma |
title_fullStr | Atypical Histological Features as Risk Factors for Recurrence in Newly Diagnosed WHO Grade I Meningioma |
title_full_unstemmed | Atypical Histological Features as Risk Factors for Recurrence in Newly Diagnosed WHO Grade I Meningioma |
title_short | Atypical Histological Features as Risk Factors for Recurrence in Newly Diagnosed WHO Grade I Meningioma |
title_sort | atypical histological features as risk factors for recurrence in newly diagnosed who grade i meningioma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592816/ https://www.ncbi.nlm.nih.gov/pubmed/34470989 http://dx.doi.org/10.2176/nmc.oa.2021-0153 |
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