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Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise

Vascular conductance (VC) regulation involves a continuous balance between metabolic vasodilation and sympathetic vasoconstriction. Endurance exercise challenges the sympathetic control on VC due to attenuated sympathetic receptor responsiveness and persistence of muscle vasodilation, especially in...

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Autores principales: Gentilin, Alessandro, Tarperi, Cantor, Skroce, Kristina, Cevese, Antonio, Schena, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Society of Smooth Muscle Research 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592823/
https://www.ncbi.nlm.nih.gov/pubmed/34789634
http://dx.doi.org/10.1540/jsmr.57.
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author Gentilin, Alessandro
Tarperi, Cantor
Skroce, Kristina
Cevese, Antonio
Schena, Federico
author_facet Gentilin, Alessandro
Tarperi, Cantor
Skroce, Kristina
Cevese, Antonio
Schena, Federico
author_sort Gentilin, Alessandro
collection PubMed
description Vascular conductance (VC) regulation involves a continuous balance between metabolic vasodilation and sympathetic vasoconstriction. Endurance exercise challenges the sympathetic control on VC due to attenuated sympathetic receptor responsiveness and persistence of muscle vasodilation, especially in endurance athletes, predisposing them to blood pressure control dysfunctions. This study assessed whether acute handgrip-mediated sympathetic activation (SYMP) restrains sudden leg vasodilation before and after a half-marathon. Prior to, and within the 20 min following the race, 11 well-trained runners underwent two single passive leg movement (SPLM) tests to suddenly induce leg vasodilation, one without and the other during SYMP. Leg blood flow and mean arterial pressure were measured to assess changes in leg VC. Undertaking 60 sec of SYMP reduced the baseline leg VC both before (4.0 ± 1.0 vs. 3.3 ± 0.7 ml/min/mmHg; P=0.01; NO SYMP vs. SYMP, respectively) and after the race (4.6 ± 0.8 vs. 3.9 ± 0.8 ml/min/mmHg; P=0.01). However, SYMP did not reduce leg peak vasodilation immediately after the SPLM either before (11.5 ± 4.0 vs. 12.2 ± 3.8 ml/min/mmHg; P=0.35) or after the race (7.2 ± 2.0 vs. 7.3 ± 2.6 ml/min/mmHg; P=0.96). Furthermore, SYMP did not blunt the mean leg vasodilation over the 60 sec after the SPLM before (5.1 ± 1.7 vs. 5.9 ± 2.5 ml/min/mmHg; P=0.14) or after the race (4.8 ± 1.3 vs. 4.2 ± 1.5 ml/min/mmHg; P=0.26). This data suggest that the release of local vasoactive agents effectively opposes any preceding handgrip-mediated augmented vasoconstriction in endurance athletes before and after a half-marathon. Handgrip-mediated SYMP might improve normal vasoconstriction while athletes are still, but not necessarily while they move, as movements can induce a release of vasoactive molecules.
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spelling pubmed-85928232021-11-23 Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise Gentilin, Alessandro Tarperi, Cantor Skroce, Kristina Cevese, Antonio Schena, Federico J Smooth Muscle Res Original Vascular conductance (VC) regulation involves a continuous balance between metabolic vasodilation and sympathetic vasoconstriction. Endurance exercise challenges the sympathetic control on VC due to attenuated sympathetic receptor responsiveness and persistence of muscle vasodilation, especially in endurance athletes, predisposing them to blood pressure control dysfunctions. This study assessed whether acute handgrip-mediated sympathetic activation (SYMP) restrains sudden leg vasodilation before and after a half-marathon. Prior to, and within the 20 min following the race, 11 well-trained runners underwent two single passive leg movement (SPLM) tests to suddenly induce leg vasodilation, one without and the other during SYMP. Leg blood flow and mean arterial pressure were measured to assess changes in leg VC. Undertaking 60 sec of SYMP reduced the baseline leg VC both before (4.0 ± 1.0 vs. 3.3 ± 0.7 ml/min/mmHg; P=0.01; NO SYMP vs. SYMP, respectively) and after the race (4.6 ± 0.8 vs. 3.9 ± 0.8 ml/min/mmHg; P=0.01). However, SYMP did not reduce leg peak vasodilation immediately after the SPLM either before (11.5 ± 4.0 vs. 12.2 ± 3.8 ml/min/mmHg; P=0.35) or after the race (7.2 ± 2.0 vs. 7.3 ± 2.6 ml/min/mmHg; P=0.96). Furthermore, SYMP did not blunt the mean leg vasodilation over the 60 sec after the SPLM before (5.1 ± 1.7 vs. 5.9 ± 2.5 ml/min/mmHg; P=0.14) or after the race (4.8 ± 1.3 vs. 4.2 ± 1.5 ml/min/mmHg; P=0.26). This data suggest that the release of local vasoactive agents effectively opposes any preceding handgrip-mediated augmented vasoconstriction in endurance athletes before and after a half-marathon. Handgrip-mediated SYMP might improve normal vasoconstriction while athletes are still, but not necessarily while they move, as movements can induce a release of vasoactive molecules. Japan Society of Smooth Muscle Research 2021-11-17 2021 /pmc/articles/PMC8592823/ /pubmed/34789634 http://dx.doi.org/10.1540/jsmr.57. Text en ©2021 The Japan Society of Smooth Muscle Research https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original
Gentilin, Alessandro
Tarperi, Cantor
Skroce, Kristina
Cevese, Antonio
Schena, Federico
Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise
title Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise
title_full Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise
title_fullStr Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise
title_full_unstemmed Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise
title_short Effect of acute sympathetic activation on leg vasodilation before and after endurance exercise
title_sort effect of acute sympathetic activation on leg vasodilation before and after endurance exercise
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592823/
https://www.ncbi.nlm.nih.gov/pubmed/34789634
http://dx.doi.org/10.1540/jsmr.57.
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