Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature

Undifferentiated mesenchymal tumors arising from the inner lining (intima) of large arteries are classified as intimal sarcomas (ISA) with MDM2 amplification as their molecular hallmark. Interestingly, undifferentiated pleomorphic sarcomas (UPS) of the heart have recently been suggested to represent...

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Detalles Bibliográficos
Autores principales: Koelsche, Christian, Benhamida, Jamal K., Kommoss, Felix K. F., Stichel, Damian, Jones, David T. W., Pfister, Stefan M., Heilig, Christoph E., Fröhling, Stefan, Stenzinger, Albrecht, Buslei, Rolf, Mentzel, Thomas, Baumhoer, Daniel, Ladanyi, Marc, Antonescu, Cristina R., Flucke, Uta, Gorp, Joost van, Bode-Lesniewska, Beata, Deimling, Andreas von, Mechtersheimer, Gunhild
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592836/
https://www.ncbi.nlm.nih.gov/pubmed/34312479
http://dx.doi.org/10.1038/s41379-021-00874-y

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