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Insertion-trigger residues differentially modulate endosomal escape by cytotoxic necrotizing factor toxins

The cellular specificity, potency, and modular nature of bacterial protein toxins enable their application for targeted cytosolic delivery of therapeutic cargo. Efficient endosomal escape is a critical step in the design of bacterial toxin-inspired drug delivery (BTIDD) vehicles to avoid lysosomal d...

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Detalles Bibliográficos
Autores principales:	Haywood, Elizabeth E., Handy, Nicholas B., Lopez, James W., Ho, Mengfei, Wilson, Brenda A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592880/ https://www.ncbi.nlm.nih.gov/pubmed/34715130 http://dx.doi.org/10.1016/j.jbc.2021.101347

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