Cargando…

Naturally occurring cancer-associated mutations disrupt oligomerization and activity of protein arginine methyltransferase 1 (PRMT1)

Protein arginine methylation is a posttranslational modification catalyzed by the protein arginine methyltransferase (PRMT) enzyme family. Dysregulated protein arginine methylation is linked to cancer and a variety of other human diseases. PRMT1 is the predominant PRMT isoform in mammalian cells and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Price, Owen M., Thakur, Abhishek, Ortolano, Ariana, Towne, Arianna, Velez, Caroline, Acevedo, Orlando, Hevel, Joan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592882/ https://www.ncbi.nlm.nih.gov/pubmed/34688662 http://dx.doi.org/10.1016/j.jbc.2021.101336

Ejemplares similares

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor
por: Feoli, Alessandra, et al.
Publicado: (2023)

Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation
por: Dashti, Parisa, et al.
Publicado: (2023)

Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification
por: Ito, Tatsuo, et al.
Publicado: (2009)

KAP1 is a Novel Substrate for the Arginine Methyltransferase PRMT5
por: di Caprio, Roberta, et al.
Publicado: (2015)

The protein arginine methyltransferases CARM1 and PRMT1 cooperate in gene regulation
por: Kleinschmidt, Markus A., et al.
Publicado: (2008)

The arginine methyltransferase PRMT1 regulates IGF-1 signaling in breast cancer
por: Choucair, Ali, et al.
Publicado: (2019)

Structure and Function of Protein Arginine Methyltransferase PRMT7
por: Halabelian, Levon, et al.
Publicado: (2021)

Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)
por: Gunnell, Emma A., et al.
Publicado: (2020)

Arginine Methyltransferase PRMT1 Regulates p53 Activity in Breast Cancer
por: Liu, Li-Ming, et al.
Publicado: (2021)

The arginine methyltransferase Prmt1 coordinates the germline arginine methylome essential for spermatogonial homeostasis and male fertility
por: Azhar, Muhammad, et al.
Publicado: (2023)

Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer
por: Shailesh, Harshita, et al.
Publicado: (2018)

Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons
por: Dong, Rui, et al.
Publicado: (2021)

Structure, Activity and Function of the PRMT2 Protein Arginine Methyltransferase
por: Cura, Vincent, et al.
Publicado: (2021)

The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine
por: Hernandez, Juan E, et al.
Publicado: (2023)

The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation
por: Bai, Xuemei, et al.
Publicado: (2022)

Genome wide comparative analysis of the effects of PRMT5 and PRMT4/CARM1 arginine methyltransferases on the Arabidopsis thaliana transcriptome
por: Hernando, Carlos E, et al.
Publicado: (2015)

Transcriptional repression of hypoxia-inducible factor-1 (HIF-1) by the protein arginine methyltransferase PRMT1
por: Lafleur, Véronique N., et al.
Publicado: (2014)

Characterization of protein arginine methyltransferase of TgPRMT5 in Toxoplasma gondii
por: Liu, Min, et al.
Publicado: (2019)

PRMT7: A Pivotal Arginine Methyltransferase in Stem Cells and Development
por: Wang, Bingyuan, et al.
Publicado: (2021)

Protein Arginine Methyltransferase 5 (PRMT5) Mutations in Cancer Cells
por: Rasheed, Shayaan, et al.
Publicado: (2023)

Protein arginine methyltransferase 1 (PRMT1) represses MHC II transcription in macrophages by methylating CIITA
por: Fan, Zhiwen, et al.
Publicado: (2017)

PRMT1 Arginine Methyltransferase Accumulates in Cytoplasmic Bodies that Respond to Selective Inhibition and DNA Damage
por: Suchánková, J., et al.
Publicado: (2014)

The Critical Role of Protein Arginine Methyltransferase prmt8 in Zebrafish Embryonic and Neural Development Is Non-Redundant with Its Paralogue prmt1
por: Lin, Yu-ling, et al.
Publicado: (2013)

Arginine methyltransferases PRMT2 and PRMT3 are essential for biosynthesis of plant-polysaccharide-degrading enzymes in Penicillium oxalicum
por: Zhao, Shuai, et al.
Publicado: (2023)

The Development of Tetrazole Derivatives as Protein Arginine Methyltransferase I (PRMT I) Inhibitors
por: Sun, Yutong, et al.
Publicado: (2019)

The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLAR(L) in human lung cancer cells
por: Li, Mingyue, et al.
Publicado: (2019)

The expression of myogenic microRNAs indirectly requires protein arginine methyltransferase (Prmt)5 but directly requires Prmt4
por: Mallappa, Chandrashekara, et al.
Publicado: (2011)

Toxoplasma gondii Arginine Methyltransferase 1 (PRMT1) Is Necessary for Centrosome Dynamics during Tachyzoite Cell Division
por: El Bissati, Kamal, et al.
Publicado: (2016)

The protein arginine methyltransferases (PRMTs) PRMT1 and CARM1 as candidate epigenetic drivers in prostate cancer progression
por: Grypari, Ioanna Maria, et al.
Publicado: (2021)

Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs
por: Dhar, Surbhi, et al.
Publicado: (2013)

Identification and Characterization of New Molecular Partners for the Protein Arginine Methyltransferase 6 (PRMT6)
por: Lo Sardo, Alessandra, et al.
Publicado: (2013)

Acquisition of regeneration competence in adult fibroblasts is accompanied by upregulation of arginine methyltransferase PRMT8
por: Runqe, Sarah, et al.
Publicado: (2013)

The Arginine Methyltransferase PRMT6 Cooperates with Polycomb Proteins in Regulating HOXA Gene Expression
por: Stein, Claudia, et al.
Publicado: (2016)

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)
por: Kaniskan, H. Ümit, et al.
Publicado: (2017)

Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors
por: Lin, Hong, et al.
Publicado: (2019)

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD
por: Günes Günsel, Gizem, et al.
Publicado: (2022)

Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis
por: Lai, Yandong, et al.
Publicado: (2023)

A peptoid-based inhibitor of protein arginine methyltransferase 1 (PRMT1) induces apoptosis and autophagy in cancer cells
por: Brekker, Mollie A., et al.
Publicado: (2022)

Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer
por: Ryu, Tae Young, et al.
Publicado: (2019)

Arginine Methyltransferase PRMT7 Deregulates Expression of RUNX1 Target Genes in T-Cell Acute Lymphoblastic Leukemia
por: Oksa, Laura, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kajp01bb0realj43753e4h4u20