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Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction

Inflammation is a hallmark of the period after a myocardial infarction (MI) that is either promoted or resolved by distinct subtypes of circulating inflammatory cells. The three main monocyte subpopulations play different roles inflammation. This study examined whether the type of MI (type 1 or type...

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Autores principales: Askari, Noushin, Lipps, Christoph, Voss, Sandra, Staubach, Nora, Grün, Dimitri, Klingenberg, Roland, von Jeinsen, Beatrice, Wolter, Jan Sebastian, Kriechbaum, Steffen, Dörr, Oliver, Nef, Holger, Liebetrau, Christoph, Hamm, Christian W., Keller, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592918/
https://www.ncbi.nlm.nih.gov/pubmed/34796212
http://dx.doi.org/10.3389/fcvm.2021.741890
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author Askari, Noushin
Lipps, Christoph
Voss, Sandra
Staubach, Nora
Grün, Dimitri
Klingenberg, Roland
von Jeinsen, Beatrice
Wolter, Jan Sebastian
Kriechbaum, Steffen
Dörr, Oliver
Nef, Holger
Liebetrau, Christoph
Hamm, Christian W.
Keller, Till
author_facet Askari, Noushin
Lipps, Christoph
Voss, Sandra
Staubach, Nora
Grün, Dimitri
Klingenberg, Roland
von Jeinsen, Beatrice
Wolter, Jan Sebastian
Kriechbaum, Steffen
Dörr, Oliver
Nef, Holger
Liebetrau, Christoph
Hamm, Christian W.
Keller, Till
author_sort Askari, Noushin
collection PubMed
description Inflammation is a hallmark of the period after a myocardial infarction (MI) that is either promoted or resolved by distinct subtypes of circulating inflammatory cells. The three main monocyte subpopulations play different roles inflammation. This study examined whether the type of MI (type 1 or type 2) or the extent of myocardial injury is associated with differences in monocyte subpopulations. For this purpose, peripheral whole blood from patients with a suspected MI was used for flow cytometric measurements of the monocyte subpopulations, and myocardial injury was classified by cardiac troponin levels in serum. In patients with acute coronary syndrome (n = 82, 62.2% male) similar proportions of the monocyte subsets were associated with the two types of MI, whereas total monocyte counts were increased in patients with substantial myocardial injury vs. those with minor injury (p = 0.045). This was accompanied by a higher proportion of intermediate (p = 0.045) and classical monocytes (p = 0.059); no difference was found for non-classical monocytes (p = 0.772). In patients with chronic coronary syndrome (n = 144, 66.5% male), an independent association with myocardial injury was also observed for classical monocytes (p = 0.01) and intermediate monocytes (p = 0.08). In conclusion, changes in monocyte subpopulation counts, particularly for classical and intermediate monocytes, were related to the extent of myocardial injury in acute and stable coronary artery disease but not to the type of MI.
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spelling pubmed-85929182021-11-17 Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction Askari, Noushin Lipps, Christoph Voss, Sandra Staubach, Nora Grün, Dimitri Klingenberg, Roland von Jeinsen, Beatrice Wolter, Jan Sebastian Kriechbaum, Steffen Dörr, Oliver Nef, Holger Liebetrau, Christoph Hamm, Christian W. Keller, Till Front Cardiovasc Med Cardiovascular Medicine Inflammation is a hallmark of the period after a myocardial infarction (MI) that is either promoted or resolved by distinct subtypes of circulating inflammatory cells. The three main monocyte subpopulations play different roles inflammation. This study examined whether the type of MI (type 1 or type 2) or the extent of myocardial injury is associated with differences in monocyte subpopulations. For this purpose, peripheral whole blood from patients with a suspected MI was used for flow cytometric measurements of the monocyte subpopulations, and myocardial injury was classified by cardiac troponin levels in serum. In patients with acute coronary syndrome (n = 82, 62.2% male) similar proportions of the monocyte subsets were associated with the two types of MI, whereas total monocyte counts were increased in patients with substantial myocardial injury vs. those with minor injury (p = 0.045). This was accompanied by a higher proportion of intermediate (p = 0.045) and classical monocytes (p = 0.059); no difference was found for non-classical monocytes (p = 0.772). In patients with chronic coronary syndrome (n = 144, 66.5% male), an independent association with myocardial injury was also observed for classical monocytes (p = 0.01) and intermediate monocytes (p = 0.08). In conclusion, changes in monocyte subpopulation counts, particularly for classical and intermediate monocytes, were related to the extent of myocardial injury in acute and stable coronary artery disease but not to the type of MI. Frontiers Media S.A. 2021-11-02 /pmc/articles/PMC8592918/ /pubmed/34796212 http://dx.doi.org/10.3389/fcvm.2021.741890 Text en Copyright © 2021 Askari, Lipps, Voss, Staubach, Grün, Klingenberg, von Jeinsen, Wolter, Kriechbaum, Dörr, Nef, Liebetrau, Hamm and Keller. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Askari, Noushin
Lipps, Christoph
Voss, Sandra
Staubach, Nora
Grün, Dimitri
Klingenberg, Roland
von Jeinsen, Beatrice
Wolter, Jan Sebastian
Kriechbaum, Steffen
Dörr, Oliver
Nef, Holger
Liebetrau, Christoph
Hamm, Christian W.
Keller, Till
Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction
title Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction
title_full Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction
title_fullStr Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction
title_full_unstemmed Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction
title_short Circulating Monocyte Subsets Are Associated With Extent of Myocardial Injury but Not With Type of Myocardial Infarction
title_sort circulating monocyte subsets are associated with extent of myocardial injury but not with type of myocardial infarction
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592918/
https://www.ncbi.nlm.nih.gov/pubmed/34796212
http://dx.doi.org/10.3389/fcvm.2021.741890
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