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Activation of whole body by high levels of polyamine intake in rats

Polyamines are important to the survival and activation of organs and tissues via a homeostatic cell-metabolic process, and the polyamine content in cytoplasm decreases with aging. Decreases in cellular polyamine have been known to augment mutagenesis and cell death. Thus, supplementary polyamine in...

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Autores principales: Teratani, Takumi, Kasahara, Naoya, Ijichi, Tetsuo, Fujimoto, Yasuhiro, Sakuma, Yasunaru, Sata, Naohiro, Kitayama, Joji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592999/
https://www.ncbi.nlm.nih.gov/pubmed/34654958
http://dx.doi.org/10.1007/s00726-021-03079-4
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author Teratani, Takumi
Kasahara, Naoya
Ijichi, Tetsuo
Fujimoto, Yasuhiro
Sakuma, Yasunaru
Sata, Naohiro
Kitayama, Joji
author_facet Teratani, Takumi
Kasahara, Naoya
Ijichi, Tetsuo
Fujimoto, Yasuhiro
Sakuma, Yasunaru
Sata, Naohiro
Kitayama, Joji
author_sort Teratani, Takumi
collection PubMed
description Polyamines are important to the survival and activation of organs and tissues via a homeostatic cell-metabolic process, and the polyamine content in cytoplasm decreases with aging. Decreases in cellular polyamine have been known to augment mutagenesis and cell death. Thus, supplementary polyamine in food is important to the prevention of aging. Here we show the anti-aging effects of oral intake of polyamine using luciferase-transgenic rats. Healthy rats, 10–12 weeks old, were given foods containing 0.01% and 0.1% (w/w) of polyamine, as compared a control food without polyamine, for 4 weeks. Using a bioimaging system, the photon intensities seen in the whole bodies and livers of rats consuming 0.1% of polyamine in food were stronger than those in rats consuming 0.01% and 0% of polyamine. However, there were no differences between groups in other characteristics, such as liver damage and body weight. In conclusion, we found that polyamine intake can activate cells throughout the whole body, providing an anti-aging effect. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00726-021-03079-4.
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spelling pubmed-85929992021-11-19 Activation of whole body by high levels of polyamine intake in rats Teratani, Takumi Kasahara, Naoya Ijichi, Tetsuo Fujimoto, Yasuhiro Sakuma, Yasunaru Sata, Naohiro Kitayama, Joji Amino Acids Original Article Polyamines are important to the survival and activation of organs and tissues via a homeostatic cell-metabolic process, and the polyamine content in cytoplasm decreases with aging. Decreases in cellular polyamine have been known to augment mutagenesis and cell death. Thus, supplementary polyamine in food is important to the prevention of aging. Here we show the anti-aging effects of oral intake of polyamine using luciferase-transgenic rats. Healthy rats, 10–12 weeks old, were given foods containing 0.01% and 0.1% (w/w) of polyamine, as compared a control food without polyamine, for 4 weeks. Using a bioimaging system, the photon intensities seen in the whole bodies and livers of rats consuming 0.1% of polyamine in food were stronger than those in rats consuming 0.01% and 0% of polyamine. However, there were no differences between groups in other characteristics, such as liver damage and body weight. In conclusion, we found that polyamine intake can activate cells throughout the whole body, providing an anti-aging effect. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00726-021-03079-4. Springer Vienna 2021-10-15 2021 /pmc/articles/PMC8592999/ /pubmed/34654958 http://dx.doi.org/10.1007/s00726-021-03079-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Teratani, Takumi
Kasahara, Naoya
Ijichi, Tetsuo
Fujimoto, Yasuhiro
Sakuma, Yasunaru
Sata, Naohiro
Kitayama, Joji
Activation of whole body by high levels of polyamine intake in rats
title Activation of whole body by high levels of polyamine intake in rats
title_full Activation of whole body by high levels of polyamine intake in rats
title_fullStr Activation of whole body by high levels of polyamine intake in rats
title_full_unstemmed Activation of whole body by high levels of polyamine intake in rats
title_short Activation of whole body by high levels of polyamine intake in rats
title_sort activation of whole body by high levels of polyamine intake in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592999/
https://www.ncbi.nlm.nih.gov/pubmed/34654958
http://dx.doi.org/10.1007/s00726-021-03079-4
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