Cargando…

Regulation of Dendritic Synaptic Morphology and Transcription by the SRF Cofactor MKL/MRTF

Accumulating evidence suggests that the serum response factor (SRF) cofactor megakaryoblastic leukemia (MKL)/myocardin-related transcription factor (MRTF) has critical roles in many physiological and pathological processes in various cell types. MKL/MRTF molecules comprise MKL1/MRTFA and MKL2/MRTFB,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tabuchi, Akiko, Ihara, Daisuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593110/ https://www.ncbi.nlm.nih.gov/pubmed/34795561 http://dx.doi.org/10.3389/fnmol.2021.767842

Ejemplares similares

Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology
por: Kaneda, Marisa, et al.
Publicado: (2018)

MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells
por: Liu, Chen-Ying, et al.
Publicado: (2016)

Identification, expression and characterization of rat isoforms of the serum response factor (SRF) coactivator MKL1()
por: Ishikawa, Mitsuru, et al.
Publicado: (2013)

SRF and MKL1 Independently Inhibit Brown Adipogenesis
por: Rosenwald, Matthias, et al.
Publicado: (2017)

Migration arrest of chemoresistant leukemia cells mediated by MRTF-SRF pathway
por: Morimatsu, Maho, et al.
Publicado: (2020)

Prevention of bleomycin‐induced lung fibrosis via inhibition of the MRTF/SRF transcription pathway
por: Pawelec, Kendell M., et al.
Publicado: (2022)

NLK is required for Ras/ERK/SRF/ELK signaling to tune skeletal muscle development by phosphorylating SRF and antagonizing the SRF/MKL pathway
por: Li, Shang-Ze, et al.
Publicado: (2022)

MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages
por: Xie, Lan
Publicado: (2014)

Lamin A/C and emerin regulate MKL1/SRF activity by modulating actin dynamics
por: Ho, Chin Yee, et al.
Publicado: (2013)

CBP and SRF co-regulate dendritic growth and synaptic maturation
por: del Blanco, Beatriz, et al.
Publicado: (2019)

Single-molecule tracking (SMT) and localization of SRF and MRTF transcription factors during neuronal stimulation and differentiation
por: Kuchler, Oliver, et al.
Publicado: (2022)

A β2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation
por: Guenther, Carla, et al.
Publicado: (2019)

HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity
por: Zhang, Mengxue, et al.
Publicado: (2018)

Actomyosin and the MRTF-SRF pathway downregulate FGFR1 in mesenchymal stromal cells
por: Zonderland, Jip, et al.
Publicado: (2020)

The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression
por: Fernández-Barrera, Jaime, et al.
Publicado: (2018)

Circadian clock control of MRTF/SRF pathway suppresses beige adipocyte thermogenic recruitment
por: Xiong, Xuekai, et al.
Publicado: (2022)

RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1
por: Rajakylä, Eeva Kaisa, et al.
Publicado: (2015)

MKL/SRF and Bcl6 mutual transcriptional repression safeguards the fate and positioning of neocortical progenitor cells mediated by RhoA
por: Cossard, Alexia, et al.
Publicado: (2023)

Exercise‐dependent increases in protein synthesis are accompanied by chromatin modifications and increased MRTF‐SRF signalling
por: Solagna, Francesca, et al.
Publicado: (2020)

Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent
por: Selvaraj, Ahalya, et al.
Publicado: (2004)

Cyclosporine A inhibits MRTF‐SRF signaling through Na(+)/K(+) ATPase inhibition and actin remodeling
por: Burat, Bastien, et al.
Publicado: (2019)

Non-canonical hedgehog pathway activation by MKL1/SRF promotes drug-resistance in basal cell carcinomas
por: Whitson, Ramon J., et al.
Publicado: (2018)

Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks
por: Evelyn, Chris R., et al.
Publicado: (2016)

Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
por: Marco, Sergi, et al.
Publicado: (2021)

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics
por: Foster, Charles T., et al.
Publicado: (2017)

In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis
por: Tagalakis, Aristides D., et al.
Publicado: (2018)

Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis
por: Yu-Wai-Man, Cynthia, et al.
Publicado: (2017)

Paracrine HB-EGF signaling reduce enhanced contractile and energetic state of activated decidual fibroblasts by rebalancing SRF-MRTF-TCF transcriptional axis
por: Afzal, Junaid, et al.
Publicado: (2022)

Dendritic spinule-mediated structural synaptic plasticity: Implications for development, aging, and psychiatric disease
por: Zaccard, Colleen R., et al.
Publicado: (2023)

Activating transcription factor 4 (ATF4) modulates post-synaptic development and dendritic spine morphology
por: Liu, Jin, et al.
Publicado: (2014)

Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts
por: Kepser, Lara-Jane, et al.
Publicado: (2021)

Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations
por: Le Dour, Caroline, et al.
Publicado: (2022)

Ultrastructure of Dendritic Spines: Correlation Between Synaptic and Spine Morphologies
por: Arellano, Jon I., et al.
Publicado: (2007)

Editorial: Regulation of synaptic structure and function
por: Shao, Zhiyong, et al.
Publicado: (2022)

Functional interactions between the Forkhead transcription factor FOXK1 and the MADS-box protein SRF
por: Freddie, Cecilie T., et al.
Publicado: (2007)

Transient α-helices in the disordered RPEL motifs of the serum response factor coactivator MKL1
por: Mizuguchi, Mineyuki, et al.
Publicado: (2014)

Molecular Mechanisms of Leukocyte Migration and Its Potential Targeting—Lessons Learned From MKL1/SRF-Related Primary Immunodeficiency Diseases
por: Sprenkeler, Evelien G. G., et al.
Publicado: (2021)

ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription
por: Esnault, Cyril, et al.
Publicado: (2017)

Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum
por: Tan, Shu-yi, et al.
Publicado: (2023)

Corrigendum: Neural mechanism underlies CYLD modulation of morphology and synaptic function of medium spiny neurons in dorsolateral striatum
por: Tan, Shu-yi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tg2f5720ikd5nrfj7hnnudsj1l