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Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology

The lymphatic system is a vascular system comprising modified lymphatic endothelial cells, lymph nodes and other lymphoid organs. The system has diverse, but critical functions in both physiology and pathology, and forms an interface between the blood vascular and immune system. It is increasingly e...

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Autores principales: Tabrizi, Zarah B., Ahmed, Nada S., Horder, Joseph L., Storr, Sarah J., Benest, Andrew V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593113/
https://www.ncbi.nlm.nih.gov/pubmed/34795596
http://dx.doi.org/10.3389/fphys.2021.672987
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author Tabrizi, Zarah B.
Ahmed, Nada S.
Horder, Joseph L.
Storr, Sarah J.
Benest, Andrew V.
author_facet Tabrizi, Zarah B.
Ahmed, Nada S.
Horder, Joseph L.
Storr, Sarah J.
Benest, Andrew V.
author_sort Tabrizi, Zarah B.
collection PubMed
description The lymphatic system is a vascular system comprising modified lymphatic endothelial cells, lymph nodes and other lymphoid organs. The system has diverse, but critical functions in both physiology and pathology, and forms an interface between the blood vascular and immune system. It is increasingly evident that remodelling of the lymphatic system occurs alongside remodelling of the blood microvascular system, which is now considered a hallmark of most pathological conditions as well as being critical for normal development. Much attention has focussed on how the blood endothelium undergoes phenotypic switching in development and disease, resulting in over two decades of research to probe the mechanisms underlying the resulting heterogeneity. The lymphatic system has received less attention, and consequently there are fewer descriptions of functional and molecular heterogeneity, but differential transcription factor activity is likely an important control mechanism. Here we introduce and discuss significant transcription factors of relevance to coordinating cellular responses during lymphatic remodelling as the lymphatic endothelium dynamically changes from quiescence to actively remodelling.
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spelling pubmed-85931132021-11-17 Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology Tabrizi, Zarah B. Ahmed, Nada S. Horder, Joseph L. Storr, Sarah J. Benest, Andrew V. Front Physiol Physiology The lymphatic system is a vascular system comprising modified lymphatic endothelial cells, lymph nodes and other lymphoid organs. The system has diverse, but critical functions in both physiology and pathology, and forms an interface between the blood vascular and immune system. It is increasingly evident that remodelling of the lymphatic system occurs alongside remodelling of the blood microvascular system, which is now considered a hallmark of most pathological conditions as well as being critical for normal development. Much attention has focussed on how the blood endothelium undergoes phenotypic switching in development and disease, resulting in over two decades of research to probe the mechanisms underlying the resulting heterogeneity. The lymphatic system has received less attention, and consequently there are fewer descriptions of functional and molecular heterogeneity, but differential transcription factor activity is likely an important control mechanism. Here we introduce and discuss significant transcription factors of relevance to coordinating cellular responses during lymphatic remodelling as the lymphatic endothelium dynamically changes from quiescence to actively remodelling. Frontiers Media S.A. 2021-11-02 /pmc/articles/PMC8593113/ /pubmed/34795596 http://dx.doi.org/10.3389/fphys.2021.672987 Text en Copyright © 2021 Tabrizi, Ahmed, Horder, Storr and Benest. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Tabrizi, Zarah B.
Ahmed, Nada S.
Horder, Joseph L.
Storr, Sarah J.
Benest, Andrew V.
Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology
title Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology
title_full Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology
title_fullStr Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology
title_full_unstemmed Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology
title_short Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology
title_sort transcription factor control of lymphatic quiescence and maturation of lymphatic neovessels in development and physiology
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593113/
https://www.ncbi.nlm.nih.gov/pubmed/34795596
http://dx.doi.org/10.3389/fphys.2021.672987
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