Cargando…

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Background: Little information exists regarding the differences in the clinical and laboratory characteristics of Kikuchi-Fujimoto disease (KFD) according to age. Objective: To evaluate the clinical and laboratory characteristics of KFD according to age. Methods: The relevance of sex, age, clinical...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Hye-Young, Jo, Ha Young, Kim, Seong Heon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593182/
https://www.ncbi.nlm.nih.gov/pubmed/34796153
http://dx.doi.org/10.3389/fped.2021.745506
_version_ 1784599666500829184
author Kim, Hye-Young
Jo, Ha Young
Kim, Seong Heon
author_facet Kim, Hye-Young
Jo, Ha Young
Kim, Seong Heon
author_sort Kim, Hye-Young
collection PubMed
description Background: Little information exists regarding the differences in the clinical and laboratory characteristics of Kikuchi-Fujimoto disease (KFD) according to age. Objective: To evaluate the clinical and laboratory characteristics of KFD according to age. Methods: The relevance of sex, age, clinical features, laboratory findings, courses, and follow-up results were retrospectively evaluated in patients diagnosed with KFD at Pusan National University Hospital between 2010 and 2020. Results: Eighty patients (46 children and 34 adults) with a mean age of 21.5 ± 11.8 years (range, 3–49 years) were included in the study. Those aged 10–19 years accounted for the largest number of patients (42.5%). Among children, the male sex ratio was higher, especially for patients aged ≤ 9 years. In adults, the female sex ratio was higher, especially for patients aged 20–29 years. Fever, tenderness in the lymph node, and skin rashes were more common in children, while myalgia and weight loss were more common in adults. In children, the recurrence rate was significantly higher among boys than among girls (15.8 vs. 0.0%, P = 0.001); lower platelet count and higher CRP levels were observed among boys than among girls. EBV and ANA positivity rates were higher in boys than in girls. In adults, the recurrence rate was significantly higher in women than in men (18.2 vs. 0.0%, P = 0.005). ANA positivity rates were higher in women than in men. Conclusion: The clinical features, laboratory findings, and recurrence of KFD may differ depending on age and sex. Clinicians should be aware of this.
format Online
Article
Text
id pubmed-8593182
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-85931822021-11-17 Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age Kim, Hye-Young Jo, Ha Young Kim, Seong Heon Front Pediatr Pediatrics Background: Little information exists regarding the differences in the clinical and laboratory characteristics of Kikuchi-Fujimoto disease (KFD) according to age. Objective: To evaluate the clinical and laboratory characteristics of KFD according to age. Methods: The relevance of sex, age, clinical features, laboratory findings, courses, and follow-up results were retrospectively evaluated in patients diagnosed with KFD at Pusan National University Hospital between 2010 and 2020. Results: Eighty patients (46 children and 34 adults) with a mean age of 21.5 ± 11.8 years (range, 3–49 years) were included in the study. Those aged 10–19 years accounted for the largest number of patients (42.5%). Among children, the male sex ratio was higher, especially for patients aged ≤ 9 years. In adults, the female sex ratio was higher, especially for patients aged 20–29 years. Fever, tenderness in the lymph node, and skin rashes were more common in children, while myalgia and weight loss were more common in adults. In children, the recurrence rate was significantly higher among boys than among girls (15.8 vs. 0.0%, P = 0.001); lower platelet count and higher CRP levels were observed among boys than among girls. EBV and ANA positivity rates were higher in boys than in girls. In adults, the recurrence rate was significantly higher in women than in men (18.2 vs. 0.0%, P = 0.005). ANA positivity rates were higher in women than in men. Conclusion: The clinical features, laboratory findings, and recurrence of KFD may differ depending on age and sex. Clinicians should be aware of this. Frontiers Media S.A. 2021-11-02 /pmc/articles/PMC8593182/ /pubmed/34796153 http://dx.doi.org/10.3389/fped.2021.745506 Text en Copyright © 2021 Kim, Jo and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Kim, Hye-Young
Jo, Ha Young
Kim, Seong Heon
Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age
title Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age
title_full Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age
title_fullStr Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age
title_full_unstemmed Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age
title_short Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age
title_sort clinical and laboratory characteristics of kikuchi-fujimoto disease according to age
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593182/
https://www.ncbi.nlm.nih.gov/pubmed/34796153
http://dx.doi.org/10.3389/fped.2021.745506
work_keys_str_mv AT kimhyeyoung clinicalandlaboratorycharacteristicsofkikuchifujimotodiseaseaccordingtoage
AT johayoung clinicalandlaboratorycharacteristicsofkikuchifujimotodiseaseaccordingtoage
AT kimseongheon clinicalandlaboratorycharacteristicsofkikuchifujimotodiseaseaccordingtoage