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The Role of Succinic Acid Metabolism in Ovarian Cancer

Ovarian cancer is one of the most common malignancies and the highest mortality among gynecological malignancy. The standard therapy options for patients with ovarian cancer are cytoreductive surgery and chemotherapy, and although most patients do better with standard treatment, it is easy to relaps...

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Autores principales: Xia, Lei, Zhang, Hairong, Wang, Xuezhen, Zhang, Xiaoyu, Nie, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593202/
https://www.ncbi.nlm.nih.gov/pubmed/34796116
http://dx.doi.org/10.3389/fonc.2021.769196
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author Xia, Lei
Zhang, Hairong
Wang, Xuezhen
Zhang, Xiaoyu
Nie, Ke
author_facet Xia, Lei
Zhang, Hairong
Wang, Xuezhen
Zhang, Xiaoyu
Nie, Ke
author_sort Xia, Lei
collection PubMed
description Ovarian cancer is one of the most common malignancies and the highest mortality among gynecological malignancy. The standard therapy options for patients with ovarian cancer are cytoreductive surgery and chemotherapy, and although most patients do better with standard treatment, it is easy to relapse and be resistant to chemotherapy. Therefore, it is important to find new therapeutic strategies. More recently, metabolic reprogramming has been recognized as a hallmark of cancer and has become a potential target for tumor therapy. Mutations of metabolic enzymes are closely related to the development of ovarian cancer. The metabolic reprogramming of ovarian cancer not only provides energy to tumor cells, but also participates in various biological processes as signaling molecules. Succinic acid (SA) is an important metabolic intermediate involved in a number of metabolic pathways, such as TCA cycle and glutamine metabolism, and is also widely present in a variety of plants and vegetables. Studies show abnormal SA metabolism in many tumors and affect tumor formation through a variety of mechanisms. But the role of SA in ovarian cancer is less studied. This paper reviews the role of SA and its abnormal metabolic pathway in ovarian cancer.
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spelling pubmed-85932022021-11-17 The Role of Succinic Acid Metabolism in Ovarian Cancer Xia, Lei Zhang, Hairong Wang, Xuezhen Zhang, Xiaoyu Nie, Ke Front Oncol Oncology Ovarian cancer is one of the most common malignancies and the highest mortality among gynecological malignancy. The standard therapy options for patients with ovarian cancer are cytoreductive surgery and chemotherapy, and although most patients do better with standard treatment, it is easy to relapse and be resistant to chemotherapy. Therefore, it is important to find new therapeutic strategies. More recently, metabolic reprogramming has been recognized as a hallmark of cancer and has become a potential target for tumor therapy. Mutations of metabolic enzymes are closely related to the development of ovarian cancer. The metabolic reprogramming of ovarian cancer not only provides energy to tumor cells, but also participates in various biological processes as signaling molecules. Succinic acid (SA) is an important metabolic intermediate involved in a number of metabolic pathways, such as TCA cycle and glutamine metabolism, and is also widely present in a variety of plants and vegetables. Studies show abnormal SA metabolism in many tumors and affect tumor formation through a variety of mechanisms. But the role of SA in ovarian cancer is less studied. This paper reviews the role of SA and its abnormal metabolic pathway in ovarian cancer. Frontiers Media S.A. 2021-11-02 /pmc/articles/PMC8593202/ /pubmed/34796116 http://dx.doi.org/10.3389/fonc.2021.769196 Text en Copyright © 2021 Xia, Zhang, Wang, Zhang and Nie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xia, Lei
Zhang, Hairong
Wang, Xuezhen
Zhang, Xiaoyu
Nie, Ke
The Role of Succinic Acid Metabolism in Ovarian Cancer
title The Role of Succinic Acid Metabolism in Ovarian Cancer
title_full The Role of Succinic Acid Metabolism in Ovarian Cancer
title_fullStr The Role of Succinic Acid Metabolism in Ovarian Cancer
title_full_unstemmed The Role of Succinic Acid Metabolism in Ovarian Cancer
title_short The Role of Succinic Acid Metabolism in Ovarian Cancer
title_sort role of succinic acid metabolism in ovarian cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593202/
https://www.ncbi.nlm.nih.gov/pubmed/34796116
http://dx.doi.org/10.3389/fonc.2021.769196
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