Clinical Impact of Cachexia in Head and Neck Cancer Patients Who Received Chemoradiotherapy

PURPOSE: There have been few reports on the evaluation of cancer cachexia based on skeletal muscle mass index (SMI) in patients with head and neck cancer. PATIENTS AND METHODS: One hundred and ninety-two head and neck cancer patients were enrolled. In definitive and adjuvant chemoradiotherapy settin...

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Detalles Bibliográficos
Autores principales: Hayashi, Naomi, Sato, Yasuyoshi, Fujiwara, Yu, Fukuda, Naoki, Wang, Xiaofei, Nakano, Kenji, Urasaki, Testuya, Ohmoto, Akihiro, Ono, Makiko, Tomomatsu, Junichi, Sato, Yukiko, Mitani, Hiroki, Toshiyasu, Takashi, Takahashi, Shunji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593206/
https://www.ncbi.nlm.nih.gov/pubmed/34795523
http://dx.doi.org/10.2147/CMAR.S329581
Descripción
Sumario:PURPOSE: There have been few reports on the evaluation of cancer cachexia based on skeletal muscle mass index (SMI) in patients with head and neck cancer. PATIENTS AND METHODS: One hundred and ninety-two head and neck cancer patients were enrolled. In definitive and adjuvant chemoradiotherapy settings, clinical outcomes were compared between cachexia and non-cachexia patients. RESULTS: Forty patients were diagnosed with cachexia (20.8%). In the definitive setting, overall survival (OS) was significantly shorter in the cachexia group (3-year OS: 50.0% vs 88.5%; p < 0.01), and multivariate analysis identified UICC stage IV, baseline albumin of <4 and cachexia as poor prognostic factors. However, cachexia was not significant in the adjuvant setting. CONCLUSION: Cancer cachexia was negatively associated with prognosis in patients with HNC who received definitive chemoradiotherapy. Nutritional intervention during chemoradiotherapy may improve survival in these patients.

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