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APE2 Is a General Regulator of the ATR-Chk1 DNA Damage Response Pathway to Maintain Genome Integrity in Pancreatic Cancer Cells

The maintenance of genome integrity and fidelity is vital for the proper function and survival of all organisms. Recent studies have revealed that APE2 is required to activate an ATR-Chk1 DNA damage response (DDR) pathway in response to oxidative stress and a defined DNA single-strand break (SSB) in...

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Detalles Bibliográficos
Autores principales:	Hossain, Md Akram, Lin, Yunfeng, Driscoll, Garrett, Li, Jia, McMahon, Anne, Matos, Joshua, Zhao, Haichao, Tsuchimoto, Daisuke, Nakabeppu, Yusaku, Zhao, Jianjun, Yan, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593216/ https://www.ncbi.nlm.nih.gov/pubmed/34796173 http://dx.doi.org/10.3389/fcell.2021.738502

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