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Profile of serum cytokine concentrations in patients with gouty arthritis

OBJECTIVE: This study aimed to analyze the changes in serum inflammatory cytokines and anti-inflammatory cytokines in patients with gouty arthritis (GA). METHODS: The clinical data and serum samples in patients with gouty arthritis and those in healthy volunteers were collected in China-Japan Friend...

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Autores principales: Zhang, Tie, Wang, Guozhen, Zheng, Jing, Li, Shirui, Xu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593300/
https://www.ncbi.nlm.nih.gov/pubmed/34772308
http://dx.doi.org/10.1177/03000605211055618
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author Zhang, Tie
Wang, Guozhen
Zheng, Jing
Li, Shirui
Xu, Jing
author_facet Zhang, Tie
Wang, Guozhen
Zheng, Jing
Li, Shirui
Xu, Jing
author_sort Zhang, Tie
collection PubMed
description OBJECTIVE: This study aimed to analyze the changes in serum inflammatory cytokines and anti-inflammatory cytokines in patients with gouty arthritis (GA). METHODS: The clinical data and serum samples in patients with gouty arthritis and those in healthy volunteers were collected in China-Japan Friendship Hospital from July 2018 to January 2019. Serum cytokine concentrations in patients with GA and volunteers (controls) were determined by a chemiluminescence method. The differences in cytokine concentrations were compared between the two groups. RESULTS: Concentrations of serum interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-α), IL-6, IL-8, and IL-4 were significantly higher in patients with acute GA than in controls. Serum concentrations of IL-1ß, TNF-α, IL-6, IL-8, and immunoglobulin E in patients with remission of GA were significantly lower, whereas concentrations of IL-10 and interferon-γ were significantly higher, compared with those in patients with acute GA. CONCLUSION: This study shows that serum concentrations of IL-1ß, TNF-α, IL-6, IL-8, and IL-4 are significantly elevated in patients with GA, and may be involved in the pathogenesis of GA.
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spelling pubmed-85933002021-11-17 Profile of serum cytokine concentrations in patients with gouty arthritis Zhang, Tie Wang, Guozhen Zheng, Jing Li, Shirui Xu, Jing J Int Med Res Retrospective Clinical Research Report OBJECTIVE: This study aimed to analyze the changes in serum inflammatory cytokines and anti-inflammatory cytokines in patients with gouty arthritis (GA). METHODS: The clinical data and serum samples in patients with gouty arthritis and those in healthy volunteers were collected in China-Japan Friendship Hospital from July 2018 to January 2019. Serum cytokine concentrations in patients with GA and volunteers (controls) were determined by a chemiluminescence method. The differences in cytokine concentrations were compared between the two groups. RESULTS: Concentrations of serum interleukin-1 beta (IL-1ß), tumor necrosis factor-alpha (TNF-α), IL-6, IL-8, and IL-4 were significantly higher in patients with acute GA than in controls. Serum concentrations of IL-1ß, TNF-α, IL-6, IL-8, and immunoglobulin E in patients with remission of GA were significantly lower, whereas concentrations of IL-10 and interferon-γ were significantly higher, compared with those in patients with acute GA. CONCLUSION: This study shows that serum concentrations of IL-1ß, TNF-α, IL-6, IL-8, and IL-4 are significantly elevated in patients with GA, and may be involved in the pathogenesis of GA. SAGE Publications 2021-11-12 /pmc/articles/PMC8593300/ /pubmed/34772308 http://dx.doi.org/10.1177/03000605211055618 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Retrospective Clinical Research Report
Zhang, Tie
Wang, Guozhen
Zheng, Jing
Li, Shirui
Xu, Jing
Profile of serum cytokine concentrations in patients with gouty arthritis
title Profile of serum cytokine concentrations in patients with gouty arthritis
title_full Profile of serum cytokine concentrations in patients with gouty arthritis
title_fullStr Profile of serum cytokine concentrations in patients with gouty arthritis
title_full_unstemmed Profile of serum cytokine concentrations in patients with gouty arthritis
title_short Profile of serum cytokine concentrations in patients with gouty arthritis
title_sort profile of serum cytokine concentrations in patients with gouty arthritis
topic Retrospective Clinical Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593300/
https://www.ncbi.nlm.nih.gov/pubmed/34772308
http://dx.doi.org/10.1177/03000605211055618
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