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The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia

Thrombocytopenia-absent radius (TAR) syndrome is caused by RBM8A insufficiency. We generated megakaryocyte-specific Rbm8a knockout (Rbm8aKO(MK)) mice that exhibited marked thrombocytopenia, internal hemorrhage, and splenomegaly, providing evidence that genetic deficiency of Rbm8a causes a disorder o...

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Detalles Bibliográficos
Autores principales:	Su, Chun-Hao, Liao, Wei-Ju, Ke, Wei-Chi, Yang, Ruey-Bing, Tarn, Woan-Yuh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593568/ https://www.ncbi.nlm.nih.gov/pubmed/34816104 http://dx.doi.org/10.1016/j.isci.2021.103368

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