Cargando…

Principles underlying the complex dynamics of temperature entrainment by a circadian clock

Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms rem...

Descripción completa

Detalles Bibliográficos
Autores principales: Burt, Philipp, Grabe, Saskia, Madeti, Cornelia, Upadhyay, Abhishek, Merrow, Martha, Roenneberg, Till, Herzel, Hanspeter, Schmal, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593569/
https://www.ncbi.nlm.nih.gov/pubmed/34816105
http://dx.doi.org/10.1016/j.isci.2021.103370
_version_ 1784599772163735552
author Burt, Philipp
Grabe, Saskia
Madeti, Cornelia
Upadhyay, Abhishek
Merrow, Martha
Roenneberg, Till
Herzel, Hanspeter
Schmal, Christoph
author_facet Burt, Philipp
Grabe, Saskia
Madeti, Cornelia
Upadhyay, Abhishek
Merrow, Martha
Roenneberg, Till
Herzel, Hanspeter
Schmal, Christoph
author_sort Burt, Philipp
collection PubMed
description Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms remains poorly understood despite that they are potent zeitgebers. Here we investigate the entrainment of the chronobiological model organism Neurospora crassa, subject to thermocycles of different periods and fractions of warm versus cold phases, mimicking seasonal variations. Depending on the properties of these thermocycles, regularly entrained rhythms, period-doubling (frequency demultiplication) but also irregular aperiodic behavior occurs. We demonstrate that the complex nonlinear phenomena of experimentally observed entrainment dynamics can be understood by molecular mathematical modeling.
format Online
Article
Text
id pubmed-8593569
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-85935692021-11-22 Principles underlying the complex dynamics of temperature entrainment by a circadian clock Burt, Philipp Grabe, Saskia Madeti, Cornelia Upadhyay, Abhishek Merrow, Martha Roenneberg, Till Herzel, Hanspeter Schmal, Christoph iScience Article Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms remains poorly understood despite that they are potent zeitgebers. Here we investigate the entrainment of the chronobiological model organism Neurospora crassa, subject to thermocycles of different periods and fractions of warm versus cold phases, mimicking seasonal variations. Depending on the properties of these thermocycles, regularly entrained rhythms, period-doubling (frequency demultiplication) but also irregular aperiodic behavior occurs. We demonstrate that the complex nonlinear phenomena of experimentally observed entrainment dynamics can be understood by molecular mathematical modeling. Elsevier 2021-10-30 /pmc/articles/PMC8593569/ /pubmed/34816105 http://dx.doi.org/10.1016/j.isci.2021.103370 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Burt, Philipp
Grabe, Saskia
Madeti, Cornelia
Upadhyay, Abhishek
Merrow, Martha
Roenneberg, Till
Herzel, Hanspeter
Schmal, Christoph
Principles underlying the complex dynamics of temperature entrainment by a circadian clock
title Principles underlying the complex dynamics of temperature entrainment by a circadian clock
title_full Principles underlying the complex dynamics of temperature entrainment by a circadian clock
title_fullStr Principles underlying the complex dynamics of temperature entrainment by a circadian clock
title_full_unstemmed Principles underlying the complex dynamics of temperature entrainment by a circadian clock
title_short Principles underlying the complex dynamics of temperature entrainment by a circadian clock
title_sort principles underlying the complex dynamics of temperature entrainment by a circadian clock
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593569/
https://www.ncbi.nlm.nih.gov/pubmed/34816105
http://dx.doi.org/10.1016/j.isci.2021.103370
work_keys_str_mv AT burtphilipp principlesunderlyingthecomplexdynamicsoftemperatureentrainmentbyacircadianclock
AT grabesaskia principlesunderlyingthecomplexdynamicsoftemperatureentrainmentbyacircadianclock
AT madeticornelia principlesunderlyingthecomplexdynamicsoftemperatureentrainmentbyacircadianclock
AT upadhyayabhishek principlesunderlyingthecomplexdynamicsoftemperatureentrainmentbyacircadianclock
AT merrowmartha principlesunderlyingthecomplexdynamicsoftemperatureentrainmentbyacircadianclock
AT roennebergtill principlesunderlyingthecomplexdynamicsoftemperatureentrainmentbyacircadianclock
AT herzelhanspeter principlesunderlyingthecomplexdynamicsoftemperatureentrainmentbyacircadianclock
AT schmalchristoph principlesunderlyingthecomplexdynamicsoftemperatureentrainmentbyacircadianclock