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Principles underlying the complex dynamics of temperature entrainment by a circadian clock
Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms rem...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593569/ https://www.ncbi.nlm.nih.gov/pubmed/34816105 http://dx.doi.org/10.1016/j.isci.2021.103370 |
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author | Burt, Philipp Grabe, Saskia Madeti, Cornelia Upadhyay, Abhishek Merrow, Martha Roenneberg, Till Herzel, Hanspeter Schmal, Christoph |
author_facet | Burt, Philipp Grabe, Saskia Madeti, Cornelia Upadhyay, Abhishek Merrow, Martha Roenneberg, Till Herzel, Hanspeter Schmal, Christoph |
author_sort | Burt, Philipp |
collection | PubMed |
description | Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms remains poorly understood despite that they are potent zeitgebers. Here we investigate the entrainment of the chronobiological model organism Neurospora crassa, subject to thermocycles of different periods and fractions of warm versus cold phases, mimicking seasonal variations. Depending on the properties of these thermocycles, regularly entrained rhythms, period-doubling (frequency demultiplication) but also irregular aperiodic behavior occurs. We demonstrate that the complex nonlinear phenomena of experimentally observed entrainment dynamics can be understood by molecular mathematical modeling. |
format | Online Article Text |
id | pubmed-8593569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-85935692021-11-22 Principles underlying the complex dynamics of temperature entrainment by a circadian clock Burt, Philipp Grabe, Saskia Madeti, Cornelia Upadhyay, Abhishek Merrow, Martha Roenneberg, Till Herzel, Hanspeter Schmal, Christoph iScience Article Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms remains poorly understood despite that they are potent zeitgebers. Here we investigate the entrainment of the chronobiological model organism Neurospora crassa, subject to thermocycles of different periods and fractions of warm versus cold phases, mimicking seasonal variations. Depending on the properties of these thermocycles, regularly entrained rhythms, period-doubling (frequency demultiplication) but also irregular aperiodic behavior occurs. We demonstrate that the complex nonlinear phenomena of experimentally observed entrainment dynamics can be understood by molecular mathematical modeling. Elsevier 2021-10-30 /pmc/articles/PMC8593569/ /pubmed/34816105 http://dx.doi.org/10.1016/j.isci.2021.103370 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Burt, Philipp Grabe, Saskia Madeti, Cornelia Upadhyay, Abhishek Merrow, Martha Roenneberg, Till Herzel, Hanspeter Schmal, Christoph Principles underlying the complex dynamics of temperature entrainment by a circadian clock |
title | Principles underlying the complex dynamics of temperature entrainment by a circadian clock |
title_full | Principles underlying the complex dynamics of temperature entrainment by a circadian clock |
title_fullStr | Principles underlying the complex dynamics of temperature entrainment by a circadian clock |
title_full_unstemmed | Principles underlying the complex dynamics of temperature entrainment by a circadian clock |
title_short | Principles underlying the complex dynamics of temperature entrainment by a circadian clock |
title_sort | principles underlying the complex dynamics of temperature entrainment by a circadian clock |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593569/ https://www.ncbi.nlm.nih.gov/pubmed/34816105 http://dx.doi.org/10.1016/j.isci.2021.103370 |
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