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High-sensitivity C-reactive Protein and Regression of Low-grade Squamous Intraepithelial Lesion: The Role of Low-grade Inflammation in Cervical Carcinogenesis

BACKGROUND: Inflammation is emerging as a potential mechanism of cervical carcinogenesis. However, few studies have investigated the association between host inflammatory status and the natural course of cervical precursor lesion. The aim of this study was to assess the probability of LSIL regressio...

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Autores principales: Ahn, Sangjeong, Kim, Gi Jeong, Do, Sung-Im, Kim, Kyungeun, Lee, Hyunjoo, Do, In-Gu, Kim, Dong-Hoon, Chae, Seoung Wan, Ryu, Seungho, Sohn, Jin Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Epidemiological Association 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593578/
https://www.ncbi.nlm.nih.gov/pubmed/33536377
http://dx.doi.org/10.2188/jea.JE20200142
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author Ahn, Sangjeong
Kim, Gi Jeong
Do, Sung-Im
Kim, Kyungeun
Lee, Hyunjoo
Do, In-Gu
Kim, Dong-Hoon
Chae, Seoung Wan
Ryu, Seungho
Sohn, Jin Hee
author_facet Ahn, Sangjeong
Kim, Gi Jeong
Do, Sung-Im
Kim, Kyungeun
Lee, Hyunjoo
Do, In-Gu
Kim, Dong-Hoon
Chae, Seoung Wan
Ryu, Seungho
Sohn, Jin Hee
author_sort Ahn, Sangjeong
collection PubMed
description BACKGROUND: Inflammation is emerging as a potential mechanism of cervical carcinogenesis. However, few studies have investigated the association between host inflammatory status and the natural course of cervical precursor lesion. The aim of this study was to assess the probability of LSIL regression, associated with an inflammatory biomarker, high-sensitivity C-reactive protein (hs-CRP). METHODS: In a longitudinal cohort study, female participants were examined annually or biannually using cervical cytology between 2006 and 2015. Incident LSIL cases were included in the analysis, with regression defined as at least one consecutive normal cytologic result. A total of 520 women aged 22–64 years were followed up for LSIL regression. The multivariable-adjusted hazard ratios (HRs) for LSIL regression were estimated using a parametric proportional hazards model. RESULTS: During 827.5 person-years of follow-up, 486 out of 520 subjects (93.5%) showed LSIL regression. After adjusting several important potential confounders, a higher quartile of hs-CRP levels was significantly associated with a lower rate of regression (for quartile 4 vs quartile 1, inverse HR 1.33; 95% CI, 1.04–1.69; P for trend = 0.028). CONCLUSIONS: The low rate of spontaneous regression recorded in women with higher hs-CRP lends support to the role of the perturbated host inflammatory status in cervical carcinogenesis, and suggests that hs-CRP level could help monitor LSIL.
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spelling pubmed-85935782021-12-05 High-sensitivity C-reactive Protein and Regression of Low-grade Squamous Intraepithelial Lesion: The Role of Low-grade Inflammation in Cervical Carcinogenesis Ahn, Sangjeong Kim, Gi Jeong Do, Sung-Im Kim, Kyungeun Lee, Hyunjoo Do, In-Gu Kim, Dong-Hoon Chae, Seoung Wan Ryu, Seungho Sohn, Jin Hee J Epidemiol Original Article BACKGROUND: Inflammation is emerging as a potential mechanism of cervical carcinogenesis. However, few studies have investigated the association between host inflammatory status and the natural course of cervical precursor lesion. The aim of this study was to assess the probability of LSIL regression, associated with an inflammatory biomarker, high-sensitivity C-reactive protein (hs-CRP). METHODS: In a longitudinal cohort study, female participants were examined annually or biannually using cervical cytology between 2006 and 2015. Incident LSIL cases were included in the analysis, with regression defined as at least one consecutive normal cytologic result. A total of 520 women aged 22–64 years were followed up for LSIL regression. The multivariable-adjusted hazard ratios (HRs) for LSIL regression were estimated using a parametric proportional hazards model. RESULTS: During 827.5 person-years of follow-up, 486 out of 520 subjects (93.5%) showed LSIL regression. After adjusting several important potential confounders, a higher quartile of hs-CRP levels was significantly associated with a lower rate of regression (for quartile 4 vs quartile 1, inverse HR 1.33; 95% CI, 1.04–1.69; P for trend = 0.028). CONCLUSIONS: The low rate of spontaneous regression recorded in women with higher hs-CRP lends support to the role of the perturbated host inflammatory status in cervical carcinogenesis, and suggests that hs-CRP level could help monitor LSIL. Japan Epidemiological Association 2021-12-05 /pmc/articles/PMC8593578/ /pubmed/33536377 http://dx.doi.org/10.2188/jea.JE20200142 Text en © 2021 Sangjeong Ahn et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Ahn, Sangjeong
Kim, Gi Jeong
Do, Sung-Im
Kim, Kyungeun
Lee, Hyunjoo
Do, In-Gu
Kim, Dong-Hoon
Chae, Seoung Wan
Ryu, Seungho
Sohn, Jin Hee
High-sensitivity C-reactive Protein and Regression of Low-grade Squamous Intraepithelial Lesion: The Role of Low-grade Inflammation in Cervical Carcinogenesis
title High-sensitivity C-reactive Protein and Regression of Low-grade Squamous Intraepithelial Lesion: The Role of Low-grade Inflammation in Cervical Carcinogenesis
title_full High-sensitivity C-reactive Protein and Regression of Low-grade Squamous Intraepithelial Lesion: The Role of Low-grade Inflammation in Cervical Carcinogenesis
title_fullStr High-sensitivity C-reactive Protein and Regression of Low-grade Squamous Intraepithelial Lesion: The Role of Low-grade Inflammation in Cervical Carcinogenesis
title_full_unstemmed High-sensitivity C-reactive Protein and Regression of Low-grade Squamous Intraepithelial Lesion: The Role of Low-grade Inflammation in Cervical Carcinogenesis
title_short High-sensitivity C-reactive Protein and Regression of Low-grade Squamous Intraepithelial Lesion: The Role of Low-grade Inflammation in Cervical Carcinogenesis
title_sort high-sensitivity c-reactive protein and regression of low-grade squamous intraepithelial lesion: the role of low-grade inflammation in cervical carcinogenesis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593578/
https://www.ncbi.nlm.nih.gov/pubmed/33536377
http://dx.doi.org/10.2188/jea.JE20200142
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