Cargando…

Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell Function

BACKGROUND & AIMS: One of the features of ulcerative colitis (UC) is a defect in the protective mucus layer. This has been attributed to a reduced number of goblet cells (GCs). However, it is not known whether abnormal GC mucus secretion also contributes to the reduced mucus layer. Our aims were...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Varsha, Johnson, Kelli, Yin, Jianyi, Lee, Sun, Lin, Ruxian, Yu, Huimin, In, Julie, Foulke-Abel, Jennifer, Zachos, Nicholas C., Donowitz, Mark, Rong, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593611/ https://www.ncbi.nlm.nih.gov/pubmed/34418586 http://dx.doi.org/10.1016/j.jcmgh.2021.08.010

Ejemplares similares

Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection
por: Foulke-Abel, Jennifer, et al.
Publicado: (2020)

Enterohemorrhagic E. coli (EHEC)—Secreted Serine Protease EspP Stimulates Electrogenic Ion Transport in Human Colonoid Monolayers
por: Tse, C. Ming, et al.
Publicado: (2018)

Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers
por: Yin, Jianyi, et al.
Publicado: (2018)

Ulcerative Colitis: Novel Epithelial Insights Provided by Single Cell RNA Sequencing
por: Serigado, Joao M., et al.
Publicado: (2022)

cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity
por: Tse, Chung-Ming, et al.
Publicado: (2019)

Enterohemorrhagic Escherichia coli Reduces Mucus and Intermicrovillar Bridges in Human Stem Cell-Derived Colonoids
por: In, Julie, et al.
Publicado: (2015)

The Air–Liquid Interface Reorganizes Membrane Lipids and Enhances the Recruitment of Slc26a3 to Lipid-Rich Domains in Human Colonoid Monolayers
por: Tse, C. Ming, et al.
Publicado: (2023)

Human enteroids: preclinical models of non-inflammatory diarrhea
por: Kovbasnjuk, Olga, et al.
Publicado: (2013)

Identification of Intestinal NaCl Absorptive-Anion Secretory Cells: Potential Functional Significance
por: Donowitz, Mark, et al.
Publicado: (2022)

Role of goblet cell protein CLCA1 in murine DSS colitis
por: Erickson, Nancy A., et al.
Publicado: (2016)

Uncovering the cause of ulcerative colitis
por: Roberts‐Thomson, Ian C, et al.
Publicado: (2019)

Dual roles of IL-18 in colitis through regulation of the function and quantity of goblet cells
por: Pu, Zhichen, et al.
Publicado: (2019)

Epithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury
por: In, Julie G., et al.
Publicado: (2020)

Reliability of the Endoscopic Ultrasound Ulcerative Colitis (EUS-UC) score for assessment of inflammation in patients with ulcerative colitis
por: Yan, Brian M., et al.
Publicado: (2021)

Novel Human NKCC1 Mutations Cause Defects in Goblet Cell Mucus Secretion and Chronic Inflammation
por: Koumangoye, Rainelli, et al.
Publicado: (2019)

Duodenal Obstruction Caused by the Long-term Recurrence of Appendiceal Goblet Cell Carcinoid
por: Saito, Masashi, et al.
Publicado: (2020)

The Degree of Ulcerative Colitis Burden of Luminal Inflammation score is superior to predicting medium- to long-term prognosis in patients with active ulcerative colitis
por: Chen, Liang, et al.
Publicado: (2020)

Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis
por: Han, Hongwei, et al.
Publicado: (2021)

Loss of Mucosal p32/gC1qR/HABP1 Triggers Energy Deficiency and Impairs Goblet Cell Differentiation in Ulcerative Colitis
por: Sünderhauf, Annika, et al.
Publicado: (2021)

The Role of Aeromonas-Goblet Cell Interactions in Melatonin-Mediated Improvements in Sleep Deprivation-Induced Colitis
por: Gao, Ting, et al.
Publicado: (2022)

The Prognostic Value of Residual Nonrectal Inflammation in Ulcerative Colitis
por: Kang, Eun Ae
Publicado: (2022)

Comparing the clinical application values of the Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) score and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) in patients with ulcerative colitis
por: Zhang, Xiao-Fei, et al.
Publicado: (2021)

SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression
por: Chen, Wenbo, et al.
Publicado: (2018)

Baicalin Ameliorates DSS-Induced Colitis by Protecting Goblet Cells through Activating NLRP6 Inflammasomes
por: Li, Yanan, et al.
Publicado: (2022)

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis
por: Heazlewood, Chad K, et al.
Publicado: (2008)

Cause for controversy? Infliximab in the treatment of ulcerative colitis: an update
por: Lawlor, Garrett, et al.
Publicado: (2009)

Autoantibodies as diagnostic markers and potential drivers of inflammation in ulcerative colitis
por: Jodeleit, Henrika, et al.
Publicado: (2020)

Prognostic Value of Terminal Ileal Inflammation in Patients with Ulcerative Colitis
por: Yu, Jongwook, et al.
Publicado: (2021)

Serum Immune-Inflammation Index Assessment in the Patients with Ulcerative Colitis
por: Pakoz, Zehra Betul, et al.
Publicado: (2022)

Effective immune-inﬂammation index for ulcerative colitis and activity assessments
por: Zhang, Meng-Hui, et al.
Publicado: (2021)

Critical roles of RGS16 in the mucosal inflammation of ulcerative colitis
por: Zhu, Fengqin, et al.
Publicado: (2022)

Linear IgA dermatosis after infliximab infusion for ulcerative colitis
por: Bryant, Kelli D., et al.
Publicado: (2016)

Harry Potter and the goblet of fire /
por: Rowling, J. K.
Publicado: (2000)

Goblet Cell Carcinoids of the Appendix
por: Arnold, R, et al.
Publicado: (2006)

Goblet cell carcinoid of the appendix
por: Pahlavan, Payam S, et al.
Publicado: (2005)

Goblet Cell Carcinoids of the Appendix
por: Holt, Nanna, et al.
Publicado: (2013)

Clinical significance and long-term prognosis of ulcerative colitis patients with appendiceal orifice inflammation
por: Kuk, Kyong Wook, et al.
Publicado: (2022)

ULCERATIVE COLITIS
Publicado: (1969)

Intestinal Phospholipid Disequilibrium Initiates an ER Stress Response That Drives Goblet Cell Necroptosis and Spontaneous Colitis in Mice
por: Kennelly, John P., et al.
Publicado: (2020)

Alpha-Ketoglutarate Promotes Goblet Cell Differentiation and Alters Urea Cycle Metabolites in DSS-Induced Colitis Mice
por: Bravo Iniguez, Alejandro, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3evep97vdvnrma55d61ul820me