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Nrf2 Mutation/Activation Is Dispensable for the Development of Chemically Induced Mouse HCC

BACKGROUND & AIMS: Activation of the kelch-like ECH-associated protein 1 (Keap1)–nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway has been associated with metabolic reprogramming in many tumors, including hepatocellular carcinoma (HCC). However, the contribution of Nrf2 mutations in th...

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Detalles Bibliográficos
Autores principales:	Mattu, Sandra, Zavattari, Patrizia, Kowalik, Marta Anna, Serra, Marina, Sulas, Pia, Pal, Rajesh, Puliga, Elisabetta, Sutti, Salvatore, Foglia, Beatrice, Parola, Maurizio, Albano, Emanuele, Giordano, Silvia, Perra, Andrea, Columbano, Amedeo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593617/ https://www.ncbi.nlm.nih.gov/pubmed/34530178 http://dx.doi.org/10.1016/j.jcmgh.2021.08.011

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