UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett’s Progression to Esophageal Adenocarcinoma

BACKGROUND & AIMS: TP53 mutations underlie Barrett’s esophagus (BE) progression to dysplasia and cancer. During BE progression, the ubiquitin ligase (E3) RNF128/GRAIL switches expression from isoform 2 (Iso2) to Iso1, stabilizing mutant p53. However, the ubiquitin-conjugating enzyme (E2) that pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Ray, Paramita, Nancarrow, Derek J., Ferrer-Torres, Daysha, Wang, Zhuwen, San Martinho, May, Hinton, Tonaye, Wu, Joshua H., Wu, Angeline, Turgeon, Danielle Kim, Hammer, Max A., Dame, Michael K., Lawrence, Theodore S., O’Brien, Patrick J., Spence, Jason R., Beer, David G., Ray, Dipankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593620/
https://www.ncbi.nlm.nih.gov/pubmed/34416429
http://dx.doi.org/10.1016/j.jcmgh.2021.08.003

Ejemplares similares

Ejemplares similares