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Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review
Background: The objective of this review was to evaluate the medicinal potential of Morus alba leaves on the control of type 2 diabetes mellitus (DM2). The research question was: what is the therapeutic potential of Morus alba leaves for the control of DM2? Methods: This systematic review was based...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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F1000 Research Limited
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593624/ https://www.ncbi.nlm.nih.gov/pubmed/34912543 http://dx.doi.org/10.12688/f1000research.55573.1 |
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author | Morales Ramos, Jorge Guillermo Esteves Pairazamán, Ambrocio Teodoro Mocarro Willis, María Ema Soledad Collantes Santisteban, Samuel Caldas Herrera, Emma |
author_facet | Morales Ramos, Jorge Guillermo Esteves Pairazamán, Ambrocio Teodoro Mocarro Willis, María Ema Soledad Collantes Santisteban, Samuel Caldas Herrera, Emma |
author_sort | Morales Ramos, Jorge Guillermo |
collection | PubMed |
description | Background: The objective of this review was to evaluate the medicinal potential of Morus alba leaves on the control of type 2 diabetes mellitus (DM2). The research question was: what is the therapeutic potential of Morus alba leaves for the control of DM2? Methods: This systematic review was based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The included studies were extracted from Scopus, Pubmed, ScienceDirect, Scielo, and Google Scholar; January 2015 to July 2021. Key search terms were MeSH and DeCS: Morus alba, mulberry, hypoglycemic agent. The inclusion criteria were: studies in rats administered Morus alba leaf extracts; studies that included the dimensions of lipidemia and glycemia; studies that included indicators such as fasting glucose, postprandial glucose, glycosylated hemoglobin, triglycerides, low-density lipoproteins, total cholesterol, and insulin resistance. Exclusion criteria: studies in which Morus alba leaves were administered with other plants; studies with other parts of the Morus alba plant; proteomic studies, cancer, duplicate studies, in vitro studies, and evaluation of included studies. All included investigations were evaluated for biases. Results: Of 253 studies found, 29 were included. The extracts of Morus alba leaves at the phytochemical level improve glucose uptake. Chlorogenic acid, isoquercitrin, and quercitrin, present in the leaves of Morus alba, have hypoglycemic properties and an ameliorating effect on diabetic nephropathy. This leaf has pharmacological effects such as glucose absorption, insulin secretion production, antioxidant and anti-inflammatory agent, antihyperglycemic and antihyperlipidemic activities, and obesity management. Conclusions: Morus alba leaves have pharmacological effects on DM2 that include glucose absorption, production of insulin secretion, antioxidant agent, antihyperglycemic and antihyperlipidemic activities, and obesity control. Beyond these results, there is a lack of studies on the potential and synergistic effects of Morus alba leaves' components, limiting the possibility of a more effective therapy using the plant's leaves. |
format | Online Article Text |
id | pubmed-8593624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-85936242021-12-14 Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review Morales Ramos, Jorge Guillermo Esteves Pairazamán, Ambrocio Teodoro Mocarro Willis, María Ema Soledad Collantes Santisteban, Samuel Caldas Herrera, Emma F1000Res Systematic Review Background: The objective of this review was to evaluate the medicinal potential of Morus alba leaves on the control of type 2 diabetes mellitus (DM2). The research question was: what is the therapeutic potential of Morus alba leaves for the control of DM2? Methods: This systematic review was based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The included studies were extracted from Scopus, Pubmed, ScienceDirect, Scielo, and Google Scholar; January 2015 to July 2021. Key search terms were MeSH and DeCS: Morus alba, mulberry, hypoglycemic agent. The inclusion criteria were: studies in rats administered Morus alba leaf extracts; studies that included the dimensions of lipidemia and glycemia; studies that included indicators such as fasting glucose, postprandial glucose, glycosylated hemoglobin, triglycerides, low-density lipoproteins, total cholesterol, and insulin resistance. Exclusion criteria: studies in which Morus alba leaves were administered with other plants; studies with other parts of the Morus alba plant; proteomic studies, cancer, duplicate studies, in vitro studies, and evaluation of included studies. All included investigations were evaluated for biases. Results: Of 253 studies found, 29 were included. The extracts of Morus alba leaves at the phytochemical level improve glucose uptake. Chlorogenic acid, isoquercitrin, and quercitrin, present in the leaves of Morus alba, have hypoglycemic properties and an ameliorating effect on diabetic nephropathy. This leaf has pharmacological effects such as glucose absorption, insulin secretion production, antioxidant and anti-inflammatory agent, antihyperglycemic and antihyperlipidemic activities, and obesity management. Conclusions: Morus alba leaves have pharmacological effects on DM2 that include glucose absorption, production of insulin secretion, antioxidant agent, antihyperglycemic and antihyperlipidemic activities, and obesity control. Beyond these results, there is a lack of studies on the potential and synergistic effects of Morus alba leaves' components, limiting the possibility of a more effective therapy using the plant's leaves. F1000 Research Limited 2021-10-08 /pmc/articles/PMC8593624/ /pubmed/34912543 http://dx.doi.org/10.12688/f1000research.55573.1 Text en Copyright: © 2021 Morales Ramos JG et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Systematic Review Morales Ramos, Jorge Guillermo Esteves Pairazamán, Ambrocio Teodoro Mocarro Willis, María Ema Soledad Collantes Santisteban, Samuel Caldas Herrera, Emma Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review |
title | Medicinal properties of
Morus alba for the control of type 2 diabetes mellitus: a systematic review |
title_full | Medicinal properties of
Morus alba for the control of type 2 diabetes mellitus: a systematic review |
title_fullStr | Medicinal properties of
Morus alba for the control of type 2 diabetes mellitus: a systematic review |
title_full_unstemmed | Medicinal properties of
Morus alba for the control of type 2 diabetes mellitus: a systematic review |
title_short | Medicinal properties of
Morus alba for the control of type 2 diabetes mellitus: a systematic review |
title_sort | medicinal properties of
morus alba for the control of type 2 diabetes mellitus: a systematic review |
topic | Systematic Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593624/ https://www.ncbi.nlm.nih.gov/pubmed/34912543 http://dx.doi.org/10.12688/f1000research.55573.1 |
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