Multiple autoimmunity and epitope spreading in monozygotic twins

We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibo...

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Detalles Bibliográficos
Autores principales: Avalos-Díaz, Esperanza, Pérez-Pérez, Elena, Granados, Julio, Pacheco-Tovar, Deyanira, Bollain-y-Goytia-de-la-Rosa, Juan-José, Herrera-Esparza, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593657/
https://www.ncbi.nlm.nih.gov/pubmed/34816112
http://dx.doi.org/10.1016/j.jtauto.2021.100132
Descripción
Sumario:We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.

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