Multiple autoimmunity and epitope spreading in monozygotic twins

We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibo...

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Autores principales: Avalos-Díaz, Esperanza, Pérez-Pérez, Elena, Granados, Julio, Pacheco-Tovar, Deyanira, Bollain-y-Goytia-de-la-Rosa, Juan-José, Herrera-Esparza, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593657/
https://www.ncbi.nlm.nih.gov/pubmed/34816112
http://dx.doi.org/10.1016/j.jtauto.2021.100132
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author Avalos-Díaz, Esperanza
Pérez-Pérez, Elena
Granados, Julio
Pacheco-Tovar, Deyanira
Bollain-y-Goytia-de-la-Rosa, Juan-José
Herrera-Esparza, Rafael
author_facet Avalos-Díaz, Esperanza
Pérez-Pérez, Elena
Granados, Julio
Pacheco-Tovar, Deyanira
Bollain-y-Goytia-de-la-Rosa, Juan-José
Herrera-Esparza, Rafael
author_sort Avalos-Díaz, Esperanza
collection PubMed
description We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.
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spelling pubmed-85936572021-11-22 Multiple autoimmunity and epitope spreading in monozygotic twins Avalos-Díaz, Esperanza Pérez-Pérez, Elena Granados, Julio Pacheco-Tovar, Deyanira Bollain-y-Goytia-de-la-Rosa, Juan-José Herrera-Esparza, Rafael J Transl Autoimmun Article We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here. Elsevier 2021-11-06 /pmc/articles/PMC8593657/ /pubmed/34816112 http://dx.doi.org/10.1016/j.jtauto.2021.100132 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Avalos-Díaz, Esperanza
Pérez-Pérez, Elena
Granados, Julio
Pacheco-Tovar, Deyanira
Bollain-y-Goytia-de-la-Rosa, Juan-José
Herrera-Esparza, Rafael
Multiple autoimmunity and epitope spreading in monozygotic twins
title Multiple autoimmunity and epitope spreading in monozygotic twins
title_full Multiple autoimmunity and epitope spreading in monozygotic twins
title_fullStr Multiple autoimmunity and epitope spreading in monozygotic twins
title_full_unstemmed Multiple autoimmunity and epitope spreading in monozygotic twins
title_short Multiple autoimmunity and epitope spreading in monozygotic twins
title_sort multiple autoimmunity and epitope spreading in monozygotic twins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593657/
https://www.ncbi.nlm.nih.gov/pubmed/34816112
http://dx.doi.org/10.1016/j.jtauto.2021.100132
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