Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms

INTRODUCTION: A potential role for the orphan G protein-coupled receptor, GPR21, in linking immune cell infiltration into tissues and obesity-induced insulin resistance has been proposed, although limited studies in mice are complicated by non-selective deletion of Gpr21. RESEARCH DESIGN AND METHODS...

Descripción completa

Detalles Bibliográficos
Autores principales: Riddy, Darren M, Kammoun, Helene L, Murphy, Andrew J, Bosnyak-Gladovic, Sanja, De la Fuente Gonzalez, Rocio, Merlin, Jon, Ziemann, Mark, Fabb, Stewart, Pierce, Tracie L, Diepenhorst, Natalie, Rueda, Patricia, El-Osta, Assam, Gautier, Jean-Francois, Venteclef, Nicolas, Charman, William N, Christopoulos, Arthur, Sexton, Patrick M, Summers, Roger J, Febbraio, Mark A, Delerive, Philippe, Langmead, Christopher J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Emerging Technologies, Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593704/
https://www.ncbi.nlm.nih.gov/pubmed/34782333
http://dx.doi.org/10.1136/bmjdrc-2021-002285

Ejemplares similares

Ejemplares similares