Alpha‐fetoprotein and focal nodular hyperplasia: An unconventional couple

We report the case of a 36‐year‐old patient who was initially managed for gynecomastia. The first biological analyses showed a moderately elevated alpha‐fetoprotein (AFP) level. After an endocrine etiology was excluded, an abdominal computed tomography scan showed typical focal nodular hyperplasia (...

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Detalles Bibliográficos
Autores principales: Carrier, Paul, Guyot, Anne, Debette‐Gratien, Marilyne, Fredon, Fabien, Teissier, Marie‐Pierre, Labrousse, François, Loustaud‐Ratti, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593769/
https://www.ncbi.nlm.nih.gov/pubmed/34816019
http://dx.doi.org/10.1002/jgh3.12669
Descripción
Sumario:We report the case of a 36‐year‐old patient who was initially managed for gynecomastia. The first biological analyses showed a moderately elevated alpha‐fetoprotein (AFP) level. After an endocrine etiology was excluded, an abdominal computed tomography scan showed typical focal nodular hyperplasia (FNH) proven by biopsy and showing expression of AFP in FNH cells. After follow‐up for 24 months, the serum AFP and liver radiology remained unchanged. The association between an elevated AFP and FNH is rarely described in the medical literature.

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