Impact of malnourishment on the pharmacokinetics of acetaminophen and susceptibility to acetaminophen hepatotoxicity

BACKGROUND: Acetaminophen hepatotoxicity is thought to be primarily caused by formation of the specific reactive metabolite N‐acetyl‐para‐benzo‐quinone imine (NAPQI). Malnourished individuals are at increased risk of acetaminophen‐related hepatotoxicity. We report a case of low acetaminophen clearan...

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Detalles Bibliográficos
Autores principales: Zillen, Daan, Movig, Kris L. L., Kant, Gert, Masselink, Joost B., Mian, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593780/
https://www.ncbi.nlm.nih.gov/pubmed/34815870
http://dx.doi.org/10.1002/ccr3.4611

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