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Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation

To gain insight into the signaling determinants of effector-associated DNA methylation programming among CD8 T cells, we explore the role of interleukin (IL)-12 in the imprinting of IFNg expression during CD8 T cell priming. We observe that anti-CD3/CD28-mediated stimulation of human naive CD8 T cel...

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Detalles Bibliográficos
Autores principales:	Zebley, Caitlin C., Abdelsamed, Hossam A., Ghoneim, Hazem E., Alli, Shanta, Brown, Charmaine, Haydar, Dalia, Mi, Tian, Harris, Tarsha, McGargill, Maureen A., Krenciute, Giedre, Youngblood, Ben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593824/ https://www.ncbi.nlm.nih.gov/pubmed/34644568 http://dx.doi.org/10.1016/j.celrep.2021.109796

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