Hirudin, a thrombin inhibitor, attenuates TGF-β-induced fibrosis in renal proximal tubular epithelial cells by inhibition of protease-activated receptor 1 expression via S1P/S1PR2/S1PR3 signaling

Renal interstitial fibrosis (RIF) is the final common outcome of numerous chronic kidney diseases, contributing to end-stage renal disease. Hirudin, a thrombin inhibitor, has attracted increased attention as a potential treatment approach for renal fibrosis. The present study aimed to investigate th...

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Detalles Bibliográficos
Autores principales: Lin, Qiang, Long, Chunli, Wang, Zhengang, Wang, Ronghui, Shi, Wei, Qiu, Jiwei, Mo, Junlin, Xie, Yongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593869/
https://www.ncbi.nlm.nih.gov/pubmed/34815755
http://dx.doi.org/10.3892/etm.2021.10924

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